Assessment of tumor markers CA 19-9, CEA, CA 125, and CA 242 for the early diagnosis and prognosis prediction of gallbladder cancer

Table 1 Demographic characteristics

Parameters	GBC, n = 80	Benign GB disease, n = 120	Total, n = 200	P value
Age, yr (n = 200)	57.0 (50.2-66.5)	47.0 (34.0-56.0)	52.0 (41.0-60.0)	< 0.001
Sex (n = 200), n (%)				0.951
Men	27 (33.8)	41 (34.2)	68 (34.0)
Women	53 (66.3)	79 (65.8)	132 (66.0)
BMI in kg/m2, (mean)	27.06 ± 4.46	26.50 ± 5.6	26.8 ± 4.98	0.229
Hemoglobin in g/dL	11.8 (10.8-12.6)	11.6 (10.2-12.8)	11.75 (10.6-12.70)	0.523
TLC in cells/μL	8075.0 (6759.0-9801.0)	7830.0 (6705.0-8800.0)	7846.0 (6745.0-9440.0)	0.094
Lymphocytes in cells/μL	27.4 (21.2-31.0)	26.9 (22.0-31.0)	27.0 (22.0-31.0)	0.421
Monocytes in cells/mm3	5.7 (3.4-7.9)	6.0 (4.0-7.0)	6.0 (4.0-7.30)	0.604
Neutrophils in cells/mm3	63.1 (58.2-69.6)	63.0 (59.0-67.0)	63.0 (58.92-67.77)	0.816
Eosinophils, %	3.0 (1.2-4.0)	3.5 (2.0-4.4)	3.0 (2.0-4.10)	0.023
Basophils in cells/μL	0.5 (0.3-1.0)	0.4 (0.1-1.0)	0.50 (0.20-1.0)	0.351
Bilirubin in mg/dL
Total	0.9 (0.6-1.2)	0.8 (0.6-1.1)	0.87 (0.64-1.12)	0.251
Direct	0.3 (0.2-0.5)	0.3 (0.2-0.5)	0.30 (0.20-0.52)	0.621
Indirect	0.6 (0.4-0.7)	0.4 (0.3-0.6)	0.50 (0.36-0.65)	0.015
ALP in IU/L	119.5 (80.5-163.2)	109.0 (76.2-136.2)	111.0 (78.0-146.50)	0.019
SGOT in U/L	34.0 (27.2-43.0)	28.0 (24.0-34.0)	31.0 (25.0-36.0)	0.001
SGPT in U/L	27.0 (21.0-36.5)	23.0 (21.0-30.5)	24.0 (21.0-34.0)	0.012
INR	1.1 (1.0-1.1)	1.1 (1.0-1.1)	1.12 (1.10-1.12)	0.158
Serum creatinine in mg/dL	0.8 (0.7-0.9)	0.8 (0.7-0.9)	0.80 (0.68-0.97)	0.459
BUN in mg/dL	12.3 (9.0-14.4)	12.3 (9.9-14.5)	12.30 (5.0-12.0)	0.479
GB wall thickness in mm	12.0 (9.2-15.1)	6.0 (4.0-8.0)	8.0 (5.0-12.0)	< 0.001

Data shown as median (interquartile range), unless otherwise specified. Qualitative data between benign and carcinoma groups were analyzed using Mann-Whitney U-test and quantitative data were compared with the χ² test. ALP: Alkaline phosphate; BUN: Blood urea nitrogen; INR: International normalized ratio; IQR: Interquartile range; SGOT: Serum glutamic oxaloacetic transaminase; SGPT: Serum glutamic pyruvic transaminase; TLC: Total leukocyte count; GB: Gallbladder; GBC: Gallbladder cancer.