Combination of preoperative fibrinogen and D-dimer as a prognostic indicator in pancreatic ductal adenocarcinoma patients undergoing R0 resection

Table 5 Multivariate analysis for overall survival in pancreatic ductal adenocarcinoma patients undergoing radical R0 resection

Characteristics	HR (95%CI)	Wald	P value
Age (yr)	1.285 (0.964-1.713)	2.935	0.087
> 60
≤ 60
Degree of differentiation		33.979	< 0.001
Poorly/Well	5.014 (2.737-9.185)	27.240	< 0.001
Moderately/Well	1.667 (1.031-2.696)	4.338	0.037
Capsular invasion	0.669 (0.456-0.980)	4.269	0.039
Absent
Present
Lymph node metastasis	0.669 (0.502-0.893)	7.469	0.006
Absent
Present
Preoperative CA19-9 level (U/mL)	1.613 (1.187-2.191)	9.340	0.002
> 336.4
≤ 336.4
Preoperative fibrinogen concentration (g/L)	1.603 (1.201-2.140)	10.270	0.001
> 3.31
≤ 3.31
Preoperative D-Dimer concentration (g/L)	1.355 (1.019-1.801)	4.374	0.036
> 0.53
≤ 0.53
Adjuvant therapy	1.620 (1.233-2.128)	11.983	0.001
Absent
Present