Combination of preoperative fibrinogen and D-dimer as a prognostic indicator in pancreatic ductal adenocarcinoma patients undergoing R0 resection

Table 4 Univariate analysis for overall survival in pancreatic ductal adenocarcinoma patients undergoing radical R0 resection

Characteristic	HR (95%CI)	P value
Age (yr)	1.358 (1.036-1.780)	0.027
> 60
≤ 60
Sex	1.281 (0.979-1.675)	0.071
Male
Female
Blood type	—	0.579
A
B
AB
O
Diabetes	0.903 (0.676-1.206)	0.491
Absent
Present
Smoking status	0.866 (0.635-1.181)	0.363
Absent
Present
Alcohol consumption	1.083 (0.754-1.556)	0.667
Absent
Present
Family history of cancer	1.251 (0.617-2.537)	0.535
Absent
Present
Clinical symptoms	0.600 (0.424-0.848)	0.004
Absent
Present
Open surgery approach	0.954 (0.729-1.249)	0.731
Pancreaticoduodenectomy
Distal pancreatectomy with splenectomy
Tumor location	0.954 (0.729-1.249)	0.731
Head and neck
Body and tail
Degree of differentiation	—	< 0.001
Well
Moderately
Poorly
Lymphovascular invasion	0.793 (0.590-1.065)	0.123
Absent
Present
Perineural invasion	0.905 (0.666-1.231)	0.525
Absent
Present
Capsular invasion	0.609 (0.420-0.885)	0.009
Absent
Present
Maximal tumor diameter (cm)	1.403 (1.058-1.862)	0.019
> 4
≤ 4
T stage	—	0.035
T1
T2
T3
Lymph node metastasis	0.590 (0.449-0.775)	< 0.001
Absent
Present
N stage	—	0.001
N0
N1
N2
TNM stage	—	0.003
IA
IB
IIA
IIB
III
Preoperative CA19-9 level (U/mL)	1.971 (1.469-2.644)	< 0.001
> 336.4
≤ 336.4
Preoperative fibrinogen concentration (g/L)	1.888 (1.438-2.479)	< 0.001
> 3.31
≤ 3.31
Preoperative D-Dimer concentration (g/L)	1.625 (1.244-2.123)	< 0.001
> 0.53
≤ 0.53
Adjuvant therapy	1.625 (1.244-2.123)	< 0.001
Absent
Present

TNM: Tumor, node and metastasis.