Colorectal cancer of the young displays distinct features of aggressive tumor biology: A single-center cohort study

Table 1 Study cohort

Demographic factors	CRC patients < 50 yr of age, n (%)	CRC patients ≥ 50 yr of age, n (%)	P value
Total number (%)	70 (17)	341 (83)	-
Gender
Male	44 (62.9)	209 (61.3)	0.89
Female	26 (37.1)	132 (38.7)
BMI (kg/m2)
Median (IQR)	24.7 (22.9-27)	25 (22.4-28.9)	0.3
NA	7	24
Obesity (BMI > 30kg/m2)	7 (10)	60 (21.3)	0.154
Inflammatory bowel disease1	3 (4.2)	6 (1.8)	0.19
Hereditary CRC Syndrome2	5 (7.1)	7 (2.1)	0.04a
Neoadjuvant Treatment	17 (24.3)	65 (19.1)	0.33
ASA Class
I	7 (11.3)	9 (2.9)	< 0.01b
II	43 (69.4)	182 (58.9)
III	9 (14.5)	110 (35.6)
IV	3 (4.8)	8 (2.6)
NA	8	32
High-risk drinking3
Yes	3 (4.8)	48 (15.4)	0.03a
No	60 (95.2)	267 (84.8)
NA	7	26
Current smoker			0.52
Yes	18 (28.6)	76 (24.1)
No	45 (71.4)	239 (75.9)
NA	7	26
Preoperative albumine level (g/L)
Median (IQR)	41.5 (37.3-45)	38.5 (33-42)	< 0.01b
NA	32	159

¹Crohn’s disease and ulcerative colitis.

²Lynch syndrome, familial adenomatous polyposis, MUTYH associated polyposis.

³High-risk drinking is the consumption of 4 or more drinks on any day or 8 or more drinks per week for women and 5 or more drinks on any day or 15 or more drinks per week for men[15].

NA: Data not available, significant difference between age groups (^aP < 0.05, ^bP < 0.01). CRC: Colorectal cancer; BMI: Body mass index; ASA: American Society of Anesthesiologist.