Patient-centered developments in colon- and rectal cancer with a multidisciplinary international team: From translational research to national guidelines

Figure 2 Individualized multistep treatment of a patient with primarily nonresectable isolated colorectal liver metastasis. A 35-yr-old woman with bi-lobal metastatic disease in the first step was partially resected by extended right hemihepatectomy, then treated with individualized hepatic artery infusion chemotherapy (HAI), then R0 resected by atypical resections on the left side. She then received three cycles of postoperative adjuvant chemotherapy applying the same HAI protocol. The resected metastases on the left side had shown nearly complete pathological responses. The patient lived tumor free for 7 yr and then presented with obstructive lymphangiosis in the hepatoduodenal ligament. She died due to disease progression after treatment with systemic chemotherapy.