Systematic Reviews
Copyright ©The Author(s) 2021.
World J Gastrointest Surg. Dec 27, 2021; 13(12): 1736-1753
Published online Dec 27, 2021. doi: 10.4240/wjgs.v13.i12.1736
Table 1 Basic characteristics of the included studies
Ref.
Country
Animal model (race)
Sample size (n)
Number of groups (n)
Animal per group (n)
Day at animal sacrification
Underlying animal condition that PRP was tested
PRP amount in anastomosis (and factors mixed with PRP)
Control
Primary comparison
Daglioglu et al[9], 2018TurkeyRat (Winstar-Albino)36312Day 7Normal0.5 mL PRPSimple end-end colon anastomosisPRP vs fibrin glue
Ocak et al[34], 2019TurkeyRat (Winstar-Albino)35310Day 7Hyperthermic intraperitoneal chemotherapy (HIPEC)200 μL PRP (200 μL thrombin and 100 μL calcium solution)Hyperthermic saline after anastomosisPRP vs non PRP application in rats having HIPEC with cisplatin
Yol et al[10], 2008TurkeyRat (Sprague Danwley)30310Day 7Normal1 mL PRP (0.1 mL thrombin and 1 mL calcium solution)Simple end-end colon anastomosisPRP vs bioglue
Buk et al[35], 2020TurkeyRat (Winstar-Albino)35310Day 7HIPEC1 mL PRP (1 mL thrombin and 0.5 mL calcium solution)Hyperthermic saline after anastomosisPRP vs non PRP application in rats having HIPEC with oxaliplatin
Dzhumabekov et al[25], 2019KazakhstanRabbit (Chinchillas)81327Day 7Normal0.2 mL/m2 PRPNormal saline injected in the muscular layer of end-end small bowel anastomosisPRP injection in bowel muscular layers vs soaking of bowel edges in PRP before anastomosis
Aydin et al[17], 2020TurkeyRat (Sprague Dawley)2438Day 7Normal0.7 μL PRP absorbed by suturesSimple end-end colon anastomosisHigher vs lower platelet concentration PRP-impregnated vicryl sutures
Dauser et al[26], 2020AustriaPig1644Day 0, 4, 10 and 30NormalPRF sprayEach group had one animal as a control: A simple anastomosis was performed with a circular staplerPRF vs no PRF application tested in several postoperative days
Giusto et al[28], 2017ItalyPig (Landace X Large White)824Day 8Normal1 mL PRP (50 μL calcium solution)2 out of 6 anastomoses performed in each animal used as a control anastomosis [no PRP or platelet rich in growth factors (PRGF) applied]PRP vs PRGF
Zhou et al[29], 2014ChinaRat (Sprague Dawley)30310Day 7Open abdomen. A polypropylene mesh used for abdomen closing in the open abdomen group1 mL PRPSimple end-end colon anastomosisPRP vs non PRP application in a background of open abdomen
Göksu et al[30], 2020TurkeyRat (Wistar Albino)2438Day 7HIPECPRP alone (dose not mentioned)Hyperthermic saline after anastomosisPRP vs non PRP application in rats having HIPEC with 5-fluorouracil (5-FU)
Özçay et al[16], 2018TurkeyRat (Sprague Dawley)40410Day 7Mesenteric ischemia/reperfusion injury (IR injury)PRF membrane applied around the anastomosisSimple end-end colon anastomosisPRF vs non PRF application following IR injury
Fresno et al[19], 2010SpainPig (White)3573 or 10Day 1, 2, 3, 4 and 7Normal1 mL PRP (50 μL calcium solution)1 out of 2 anastomoses performed in each animal used as a control anastomosis (no PRP or PRGF applied)PRP effect on several postoperative days
Daradka et al[27], 2019JordanRabbit (mixed-breed)30310Day 3 and 10NormalSutures submerged in 1 ml PRP solutionSimple end-end ileal anastomosisPRP vs sodium citrate coated sutures
Yalı et al[36], 2020TurkeyRat (Wistar-Albino)56412Day 5Peritonitis1 mL PRP (1 mL calcium solution)Simple end-end colon anastomosisPRP in normal abdomen vs peritonitis
Pehlivanli et al[33], 2019TurkeyRat (Wistar Albino)55510Day 10Mesenteric ischemia1 mL PRPSimple end-end colon anastomosisPRP vs Zeolite vs thymoquinone
Sozutek et al[31], 2016TurkeyRat (Wistar Albino)50410Day 7Peritonitis1 mL PRP (1 mL thrombin and 50 μL calcium solution)Simple end-end colon anastomosisPRP in normal abdomen vs peritonitis
Yamaguchi et al[18], 2012JapanRat (Sprague-Dawley)77412Day 5Normal180 μL PRP (180 units of bovine thrombin and 30 μL of calcium solution).Simple end-end colon anastomosisPlatelet poor plasma vs low vs high platelet rich plasma
Gorur et al[32], 2020TurkeyRat (Wistar Albino)50410Day 7Intraperitoneal administration of 5-FU1 mL PRP (1 mL thrombin and 50 μL of calcium solution)Simple end-end colon anastomosisPRP vs non PRP application in rats having intraperitoneal administration of 5-FU
PRP: Platelet rich plasma.