Advances in liver transplantation for unresectable colon cancer liver metastasis

Table 3 Treatment for unresectable colorectal cancer liver metastasis prior to transplantation

Ref.	Year	Treatment prior to liver transplantation
		Liver resection	Local therapy	Systemic therapy
Moore et al[12]	1964	NR	NR	NR
Demirleau et al[58]	1964	NR	NR	NR
Andersen et al[59]	2012	NR	NR	NR
Penn[13]	1991	NR	NR	NR
Pichlmayr et al[60]	1997	NR	NR	NR
Honoré et al[61]	2003	Yes	No	No
Kappel et al[9]; Hoti et al[14]	2006; 2008	NR	NR	NR
Uskudar et al[62]	2011	Yes	Yes, TACE, HAI. Yes, HAI (causing liver failure)	Yes
Kocman et al[63]	2011	Yes (Two times)	No	Yes, 1/1
Hrehoreţ et al[64]	20I3	Yes (ALPPS one stage)	Yes, radio therapy	Yes, FOLFOX AND bevacizumab
Line et al[46]	2015	No; NR	No; NR	Yes, 3/3, FLIRI/cetuximab
Caicedo et al[65]	2016	No	Yes, 1/1 RFA	Yes, 1/1, FOFIRI + cetuximab
Toso et al[66]	2017	Yes, 10/12	1/12 RFA	11/12, irinotecan, oxaliplatin, cetuximab, bevacizumab
Dueland et al[10]	2020	Yes, 4/23	2/23	Yes, 23 (1st line, 10 patients; 2nd line, 9 patients; 3rd line, 4 patients)
Yang et al[67]	2019	No	Yes, 1/1; TACE + RFA	Yes, 1/1, mFOLFOX6 + bevacizumab
Lerut et al[68]	2019	No	No	Yes, 4/4, 5-FU, Oxaliplatin irinotecan, bevacizumab,
Fernandes et al[69]	2019	Yes	Yes	FOLFOX/FOLFIRI
Dueland et al[10]	2020	4/15	NR	Yes, 15/15
Smedman et al[25]	2019	2/10	2/10 RFA	Yes, 10 patients (1st line), 10 (2nd line), 3 (3rd line)
Coubeau et al[52]	2020	NAR	NAR	Yes, 1/1

NR: Not report; RFA: Radiofrequency ablation; mFOLFOX-6: Modified 5-fluorouracil/folinic acid and oxaliplatin; FOLFIRI: Fluorouracil, folinic acid, and irinotecan.