Novel roles of lipopolysaccharide and TLR4/NF-κB signaling pathway in inflammatory response to liver injury in Budd-Chiari syndrome

doi:10.4240/wjgs.v13.i11.1448

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World Journal of Gastrointestinal Surgery

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1948-9366

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Surg. Nov 27, 2021; 13(11): 1448-1462
Published online Nov 27, 2021. doi: 10.4240/wjgs.v13.i11.1448

Table 4 Correlation between lipopolysaccharide and mRNA levels of various inflammation-related indicators

	LPS	TLR4	NF-κBp65	IFN-γ	TNF-α	IL-2
LPS	1	0.959^a	0.945^a	0.939^a	0.942^a	0.944^a
NF-κBp65	0.945^a	0.930^a	1	0.941^a	0.954^a	0.966^a
IL-2	0.939^a	0.952^a	0.941^a	1	0.982^a	0.946^a
TNF-α	0.942^a	0.953^a	0.954^a	0.982^a	1	0.954^a
IFN-γ	0.944^a	0.932^a	0.966^a	0.946^a	0.954^a	1

^aP < 0.01.

LPS: Lipopolysaccharide; TLR4: Toll-like receptor 4; NF-κB: Nuclear factor-κB; TNF-α: Tumor necrosis factor-α; IL-2: Interleukin-2; IFN-γ: Interferon-γ.

Citation: Li J, Chen XM, Zhou CZ, Fang WW, Lv WF, Cheng DL. Novel roles of lipopolysaccharide and TLR4/NF-κB signaling pathway in inflammatory response to liver injury in Budd-Chiari syndrome. World J Gastrointest Surg 2021; 13(11): 1448-1462
URL: https://www.wjgnet.com/1948-9366/full/v13/i11/1448.htm
DOI: https://dx.doi.org/10.4240/wjgs.v13.i11.1448