Novel roles of lipopolysaccharide and TLR4/NF-κB signaling pathway in inflammatory response to liver injury in Budd-Chiari syndrome

doi:10.4240/wjgs.v13.i11.1448

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 13, Issue 11

This Article

Academic Content and Language Evaluation of This Article

Academic Rules and Norms of This Article

Supplementary Materials of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (3024)

All Articles published online

The chart showing PDF series, WORD series, HTML series, Figures (1-3) series, Tables (1-6) series.

Item

Count

PDF

221

WORD

114

HTML

1300

Figures (1-3)

144

Tables (1-6)

186

Sum=1965

Publishing Process of This Article

The chart showing Browse series, Download series.

Item

Count

Browse

339

Download

720

Sum=1059

Nov 27, 2021 (publication date) through Apr 27, 2024

Times Cited of This Article

Times Cited (2)

Journal Information of This Article

Publication Name

World Journal of Gastrointestinal Surgery

ISSN

1948-9366

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Observational Study

World J Gastrointest Surg. Nov 27, 2021; 13(11): 1448-1462
Published online Nov 27, 2021. doi: 10.4240/wjgs.v13.i11.1448

Table 3 Relative protein expression levels of TLR4/NF-κB-mediated inflammation-related indicators

	TLR4	NF-κBp65	IL-2	TNF-α	IFN-γ
Control group	0.555 ± 0.066	0.317 ± 0.022	0.232 ± 0.029	0.368 ± 0.032	0.369 ± 0.023
Sham-operated group
1W	0.561 ± 0.059	0.327 ± 0.019	0.229 ± 0.028	0.366 ± 0.026	0.379 ± 0.029
3W	0.560 ± 0.068	0.313 ± 0.023	0.242 ± 0.029	0.357 ± 0.022	0.359 ± 0.026
6W	0.561 ± 0.071	0.310 ± 0.030	0.236 ± 0.027	0.369 ± 0.034	0.362 ± 0.020
12W	0.564 ± 0.070	0.309 ± 0.025	0.234 ± 0.027	0.371 ± 0.028	0.377 ± 0.028
Model group
1W	0.729 ± 0.067^a^,^b	0.678 ± 0.058^a^,^b	0.449 ± 0.057^a^,^b	0.684 ± 0.024^a^,^b	0.700 ± 0.082^a^,^b
3W	1.507 ± 0.086^a^,^b	1.416 ± 0.087^a^,^b	1.047 ± 0.058^a^,^b	1.188± 0.051^a^,^b	1.261 ± 0.073^a^,^b
6W	1.162 ± 0.070^a^,^b	1.192 ± 0.079^a^,^b	0.848 ± 0.056^a^,^b	1.050 ± 0.043^a^,^b	1.069 ± 0.090^a^,^b
12W	1.001 ± 0.072^a^,^b	0.880 ± 0.090^a^,^b	0.610 ± 0.059^a^,^b	0.835 ± 0.065^a^,^b	0.845 ± 0.063^a^,^b
Statistics	291.836	711.802	608.214	897.062	488.525
P value	< 0.0001	< 0.0001	< 0.0001	< 0.0001	< 0.0001

^aP < 0.05, comparisons between subgroups, the differences are statistically significant.

^bP < 0.05, comparisons between model subgroups, the differences are statistically significant.

TLR4: Toll-like receptor 4; NF-κB: Nuclear factor-κB; TNF-α: Tumor necrosis factor-α; IL-2: Interleukin-2; IFN-γ: Interferon-γ.

Citation: Li J, Chen XM, Zhou CZ, Fang WW, Lv WF, Cheng DL. Novel roles of lipopolysaccharide and TLR4/NF-κB signaling pathway in inflammatory response to liver injury in Budd-Chiari syndrome. World J Gastrointest Surg 2021; 13(11): 1448-1462
URL: https://www.wjgnet.com/1948-9366/full/v13/i11/1448.htm
DOI: https://dx.doi.org/10.4240/wjgs.v13.i11.1448