Onodera's Prognostic Nutritional Index is a novel and useful prognostic marker for gastrointestinal stromal tumors

Table 5 Multivariate analysis [Cox regression analysis (Enter method)] for recurrence-free survival

Factor	Hazard ratio	95%CI	P value
Primary tumor site			0.0878
Gastric	1.000	-	-
Non-gastric	2.641	0.866-8.053	-
Tumor size (cm)			0.4749
≤ 2.0	1.000	-	-
2.1-5.0	1.318	0.006-292.720	0.9201
5.1-10.0	1.612	0.006-445.888	0.8678
> 10.0	4.765	0.015-1515.961	0.5953
Mitotic index (/50 HPFs)			0.03651
≤ 5	1.000	-	-
6-10	1.896	0.518-6.949	0.3341
>10	6.791	1.554-29.672	0.01091
Tumor rupture			0.5202
No	1.000	-	-
Yes	0.589	0.117-2.957	-
NIH risk classification			0.9763
Very low risk	1.000	-	-
Low risk	0.283	0.001-64.779	0.6491
Intermediate risk	0.282	0.001-91.515	0.6681
High risk	0.277	0.001-101.508	0.6702
NLR			0.7613
< 4.34	1.000	-	-
≥ 4.34	0.838	0.268-2.620	-
PLR			0.6958
< 220.76	1.000	-	-
≥ 220.76	1.259	0.397-3.995	-
OPNI			0.04141
≥ 51.30	1.000	-	-
< 51.30	5.852	1.072-31.964	-

¹With statistical significance. NLR: Neutrophil-to-lymphocyte ratio; PLR: Platelet-to-lymphocyte ratio; OPNI: Onodera’s Prognostic Nutritional Index.