Onodera's Prognostic Nutritional Index is a novel and useful prognostic marker for gastrointestinal stromal tumors

Table 4 Univariate analysis (Kaplan-Meier) of factors for recurrence-free survival in gastrointestinal stromal tumors

Factor	1-year RFS rate (95%CI)	2-year RFS rate (95%CI)	5-year RFS rate (95%CI)	Log-rank P value
Age (yr)				0.5441
≤ 60	99.09% (93.72-99.87)	96.92% (90.66-99.01)	91.20% (80.62-96.14)
> 60	99.20% (94.46-99.89)	96.35% (90.49-98.62)	82.93% (69.26-90.91)
Gender				0.2889
Male	98.31% (93.39-99.57)	95.19% (88.74-97.99)	84.07% (71.68-91.35)
Female	100%	98.03% (92.30-99.51)	84.96% (66.88-93.61)
GI bleeding				0.1877
Yes	98.41% (89.26-99.77)	98.41% (89.26-99.77)	82.02% (63.00-91.85)
No	99.42% (95.94-99.92)	95.84% (90.90-98.12)	89.37% (80.44-94.36)
Primary site				0.0093
Gastric	99.45% (96.18-99.92)	97.47% (93.30-99.04)	89.62% (79.32-94.94)
Non-gastric	98.08% (87.12-99.73)	93.75% (81.78-97.95)	79.12% (61.86-89.21)
Tumor size				0.0012
≤ 2.0 cm	100%	98.10% (87.12-99.73)	98.10% (87.12-99.73)
2.1-5.0 cm	100%	100%	94.90% (84.98-98.33)
5.1-10.0 cm	98.51% (89.87-99.79)	92.93% (82.17-97.30)	81.55% (65.45-90.65)
> 10.0 cm	95.00% (69.46-99.28)	90.00% (65.59-97.40)	56.00% (20.71-80.77)
Predominant cell type				0.7759
Spindle	99.51 % (96.60-99.93)	97.22 % (93.41-98.84)	88.47 % (79.83-93.55)
Epithelioid	93.75 % (63.22-99.10)	93.75 % (63.22-99.10)	84.38 % (49.30-96.00)
Mixed	100%	100%	76.39 % (30.91-94.01)
Mitotic index				< 0.0001
≤ 5 per 50 HPFs	100%	98.67% (94.75-99.67)	93.47% (85.43-97.15)
6-10 per 50 HPFs	97.67% (84.61-99.67)	91.93% (76.88-97.34)	77.13% (53.86-89.67)
>10 per 50 HPFs	100%	80.00% (40.86-94.59)	50.00% (18.35-75.32)
Necrosis				0.2676
Yes	98.48% (89.72-99.79)	98.48% (89.72-99.79)	83.69% (66.12-92.63)
No	100%	95.79% (90.79-98.10)	89.58% (81.22-94.34)
Tumor rupture				0.0695
Yes	100%	100%	63.49% (23.81-86.61)
No	99.11% (96.48-99.78)	96.43% (92.62-98.29)	88.40% (79.94-93.44)
Risk classification				0.0007
Very low risk	100%	98.18% (87.78-99.74)	98.18% (87.78-99.74)
Low risk	100%	100%	97.92% (86.11-99.70)
Intermediate risk	100%	100%	85.27% (59.66-95.20)
High risk	96.61% (87.11-99.14)	89.10% (77.27-94.97)	72.82% (56.21-83.98)
NLR				0.0224
< 4.34	99.46% (96.22-99.92)	98.89% (95.65-99.72)	88.76% (78.31-94.35)
≥ 4.34	98.00% (86.63-99.72)	88.68% (74.82-95.15)	80.29% (64.11-89.73)
PLR				0.0069
< 220.76	100%	99.39% (95.75-99.91)	91.24% (80.00-96.31)
≥ 220.76	96.92% (88.25-99.22)	89.64% (78.27-95.23)	77.17% (61.76-86.99)
OPNI				0.0002
≥ 51.30	100%	100%	98.41% (89.26-99.77)
< 51.30	98.13% (92.73-99.53)	92.83% (85.49-96.53)	76.22% (62.51-85.48)
Ki-67 index				0.0592
< 2.5%	100%	98.88% (92.29-99.84)	88.03% (68.96-95.72)
≥ 2.5%	98.29% (93.34-99.57)	94.34% (87.79-97.43)	84.39% (74.22-90.79)
Albumin				0.0589
< 38.95	99.86% (96.42-99.91)	98.79% (96.65-98.72)	89.74% (76.31-93.35)
≥ 38.95	99.01% (89.63-99.82)	90.68% (86.52-96.45)	87.23% (75.11-89.63)
Lymphocyte count				0.0524
< 0.975	99.46% (96.22-99.82)	96.89% (95.15-99.02)	88.76% (78.11-94.05)
≥ 0.975	98.70% (89.93-99.62)	90.68% (86.82-95.15)	87.29% (74.11-93.53)

GI: Gastrointestinal; RFS: Recurrence-free survival; NLR: Neutrophil-to-lymphocyte ratio; PLR: Platelet-to-lymphocyte ratio; OPNI: Onodera’s Prognostic Nutritional Index.