Evaluation of prognostic factors and clinicopathological patterns of recurrence after curative surgery for colorectal cancer

Table 10 Pathological-related potential prognostic factors for liver and lung recurrence

	Recurrence, n = 58
	Liver				Lung
	No, n = 33 (55.0%)	Yes, n = 25 (41.7%)	HR (95%CI)	P value	No, n = 42 (70.0%)	Yes, n = 16 (26.7%)	HR (95%CI)	P value
Major tumor diameter, mm, mean ± SD	55.71	42.74	0.99 (0.98-1.01)	0.368	29.09	30.01	0.99 (0.97-1.01)	0.326
Pathological T stage1, n (%)
1	1 (50)	1 (50)	Reference		1 (50)	1 (50)	Reference
2	6 (75)	2 (25)	0.68 (0.06-7.50)	0.752	6 (75)	2 (25)	0.77 (0.07-8.58)	0.835
3	25 (55.6)	20 (44.4)	1.66 (0.22-12.44)	0.623	33 (73.3)	12 (26.7)	1.52 (0.19-12.45)	0.695
4	1 (50)	1 (50)	2.18 (0.13-35.75)	0.585	1 (50)	1 (50)	4.28 (0.24-76.14)	0.981
Missing	-	-			1	-
Pathological N stage1, n (%)
0	17 (65.4)	9 (34.6)	Reference		18 (69.2)	8 (30.8)	Reference
1	9 (64.3)	5 (35.7)	1.75 (0.55-5.53)	0.341	10 (71.4)	4 (28.6)	2.31 (0.60-8.88)	0.222
2	7 (41.2)	10 (58.8)	3.48 (1.31-9.27)	0.013	13 (76.5)	4 (23.5)	2.17 (0.57-8.51)	0.264
Missing	-	1			1	-
Pathological M stage1, n (%)				0.321				0.092
0	29 (58)	21 (42)	Reference		37 (74)	13 (26)	Reference
1	4 (50)	4 (50)	1.74 (0.58-5.22)		5 (62.5)	3 (37.5)	3.13 (0.83-11.79)
AJCC stage, n (%)
1	7 (77.8)	2 (22.2)	Reference		6 (66.7)	3 (33.3)	Reference
2	10 (62.5)	6 (37.5)	2.12 (0.43-10.51)	0.359	11 (68.7)	5 (31.3)	1.45 (0.33-6.33)	0.623
3	12 (48)	13 (52)	5.09 (1.10-23.52)	0.037	20 (80)	5 (20)	2.11 (0.42-10.47)	0.361
4	4 (50)	4 (50)	5.57 (0.96-32.24)	0.055	5 (62.5)	3 (37.5)	3.06 (0.85-30.09)	0.075
Retrieved LN, n (%)				0.803				0.961
< 12	6 (54.5)	5 (45.5)	Reference		8 (72.7)	3 (27.3)	Reference
≥ 12	26 (59.1)	18 (40.9)	0.90 (0.38-2.12)		31 (70.5)	13 (29.5)	0.97 (0.34-2.82)
Missing	1	2			3	-
LN ratio, mean ± SD	22 ± 18	28 ± 20	4.21 (0.79-22.42)	0.092	27 ± 21	18 ± 8	1.07 (0.96-18.11)	0.963
Colloid component, n (%)				0.367				0.200
No	6 (46.2)	7 (53.8)	Reference		8 (61.5)	5 (38.5)	Reference
Yes	11 (73.3)	4 (26.7)	0.56 (0.16-1.98)		14 (93.3)	1 (6.7)	0.24 (0.03-2.12)
Missing	16	14			20	10

¹According to the tumor node metastasis staging system. HR: Hazard ratio; CI: Confidential intervals; AJCC: American Joint Committee on Cancer; LN: Lymph nodes.