Retrospective cohort study of statin therapy effect on resected colorectal liver metastases

Table 2 Statistical analysis of prognostic factors for overall survival

Demographic, clinical and pathological factors	Overall Survival [median (range) mo]	Uni-variate analysis	Multi-variate analysis	Risk ratio (Confidence interval)
Age		0.373
< 65 yr (n = 244)	39 (3-165)
≥ 65 yr (n = 342)	35 (3-160)
Gender		0.236
Male (n = 389)	35 (3-165)
Female (n = 197)	38 (3-160)
Presentation		0.189
Synchronous (n = 225)	46 (4-165)
Metachronous (n = 361)	31 (3-160)
Neutrophil-to-lymphocyte ratio	36 (3-165)	0.219
< 5 (n = 490)	41 (4-153)
≥ 5 (n = 96)
Platelet-to-lymphocyte ratio		0.902
< 150 (n = 287)	34 (5-165) 41 (3-156)
≥ 150 (n = 299)
Neo-adjuvant chemotherapy	37 (4-165)	0.002	0.014	0.710 (0.541-0.933)
Yes (n = 135)	37 (3-160)
No (n = 451)
Statin therapy		0.459
Yes (n = 181)	34 (3-160)
No (n = 405)	38 (3-165)
Deprivation index		0.324
1 (n = 101)	31 (4-152)
2 (n = 120)	38 (3-160)
3 (n = 115)	31 (5-147)
4 (n = 142)	41 (4-159)
5 (n = 108)	36 (4-165)
Less than hemi-hepatectomy (n = 368)	38 (3-165)	0.002	0.004	1.441 (1.125-1.845)
Hemi-hepatectomy or more (n = 218)	36 (3-160)
Largest tumour size		0.079
< 5 cm (n = 406)	38 (3-159)
≥ 5 cm (n = 180)	33 (3-165)
Number of metastases		0.015	0.216	1.171 (0.912-1.504)
Solitary (n = 294)	40 (3-165)
Multiple (n = 292)	34 (4-159)
Steatosis		0.512
None (n = 426)	32 (3-165)
Mild (n = 97)	59 (5-154)
Moderate – severe (n = 63)	67 (7-159)
Lymphatic invasion		0.440
Positive (n = 67)	56 (3-160)
Negative (n = 519)	35 (3-165)
Vascular invasion		0.130
Positive (n = 264)	34(3-160)
Negative (n = 322)	40 (4-165)
Peri-neural invasion		< 0.001	0.002	0.521 (0.342-0.795)
Positive (n = 38)	27 (3-101)
Negative (n = 548)	38 (3-165)
Biliary invasion		0.530
Positive (n = 181)	37 (3-160)
Negative (n = 405)	37 (4-165)
Resection margin (R0)		< 0.001	0.004	1.462 (1.130-1.891)
R0 (n = 427)	39 (3-165)
R1 (n = 159)	34 (4-160)