In vivo expression of thrombospondin-1 suppresses the formation of peritoneal adhesion in rats

Figure 2 Quantifications of the peritoneal adhesion after experimental cecal abrasion injury. Compared with controls (no treatment; group I), the application of Seprafilm (group II) significantly reduced the adhesion score and local administration of AdTSP-1 (group III) on the injured cecum the also attenuated the severity of peritoneal adhesion score. However, systemic delivery of AdTSP-1 (group IV) did not affect the formation of adhesion. Data were analyzed using the Kruskal-Wallis test, and are presented as mean ± SD. ^aP < 0.05, Seprafilm vs control; Seprafilm vs AdTSP-1, n = 10 in each group. AdTSP-1: Adenoviral vectors encoding mouse thrombospondin 1.