Reversibility of diabetes mellitus: Narrative review of the evidence

Table 1 Bariatric surgery systematic reviews

Ref.	Type of diabetes	No. of studies included	Remission percentage (95%CI)
Chang et al[11], 2014	Not specified	164 (37 randomized clinical trials and 127 observational studies)	Randomized clinical trials: 92% (85%-97%) Observational studies: 86% (79%-92%)
Buchwald et al[12], 2004	Not specified	136	76.8% (70.7%-82.9%)
Gloy et al[13], 2013	Not specified	11	59.90%
Ashrafian et al[14], 2015	Type 1 diabetes mellitus	27	Weighted mean decrease in insulin requirement: 44.5 units 78.1% (73.8%-82.3%)
Chow et al[15], 2016	Type 1 diabetes mellitus	13	Weighted mean total daily insulin requirement decreased from 98 +/- 26 IU/d to 42 +/- 11 IU/d
Mahawar et al[16], 2016	Type 1 diabetes mellitus	15	Not reported
Buchwald et al[17], 2009	Type 2 diabetes mellitus	621	76.2% insulin free
Baskota et al[18], 2015	Type 2 diabetes mellitus	10	61.8% medication free
Goh et al[19], 2017	Type 2 diabetes mellitus	24	Remission rate Duodenal-jejunal bypass: 20%-40% Duodenal-jejunal bypass with sleeve gastrectomy: 79%-93% Duodenal-jejunal bypass sleeve: 62.5%-100% Ileal interposition with sleeve gastrectomy: 47%-95.7%
Yan et al[20]	Type 2 diabetes mellitus	6	Type 2 diabetes mellitus remission rate for roux-en-y gastric bypass vs medical treatment: OR: 76.4 (95%CI: 20.7-281.7)