Interleukin-18 polymorphism as an inflammatory index in metabolic syndrome: A preliminary study

Table 1 Biophysical and biochemical data of the study subjects

Variables	Normal weight (18-22.9 kg/m2) (n = 60)	Overweight (23-25.9 kg/m2) (n = 60)	Obese (>26 kg/m2) (n = 60)	P value
Age (yr)	26.21 ± 3.876	25.76 ± 4.059	27.30 ± 5.389	NS
BMI (kg/m2)	20.48 ± 1.30	24.20 ± 0.911	28.59 ± 3.341,2	< 0.001
Body fat (%)	19.26 ± 7.17	28.70 ± 9.101	34.89 ± 4.471,2	< 0.001
Waist circumference (cm)	88.03 ± 10.53	88.46 ± 7.69	1.9.26 ± 11.47	< 0.001
Hip circumference (cm)	77.69 ± 11.78	84.43 ± 0.69	100.41 ± 12.89	< 0.001
WHR (cm)	0.87 ± 0.05	0.871 ± 0.054	0.91 ± 0.073	< 0.001
Fasting blood glucose (mg/dL)	89.31 ± 15.23	105.59 ± 12.501	119.00 ± 25.711	< 0.001
Insulin (uIU/mL)	20.48 ± 7.95	34.96 ± 4.471	41.13 ± 7.811,2	< 0.001
HOMA-IR	4.70 ± 2.66	9.05 ± 1.341	11.88 ± 2.811,2	< 0.001
QUICKI	0.31 ± 0.02	0.27 ± 0.001	0.27 ± 0.011	< 0.001
Cholesterol (mg/dL)	145.72 ± 30.08	147.44 ± 37.91	209.06 ± 55.511,2	< 0.001
Triglyceride (mg/dL)	124.82 ± 43.92	137.58 ± 65.60	167.03 ± 55.991,2	< 0.001
HDL(mg/dL)	39.96 ± 9.38	38.37 ± 8.00	36.40 ± 6.40	NS
LDL(mg/dL)	75.43 ± 30.03	79.57 ± 40.01	134.78 ± 58.991,2	< 0.001
TNFα (pg/mL)	810 ± 1233	4455 ± 23901	4581 ± 21321	< 0.001
IL-18 (ng/L)	25.34 ± 6.57	41.96 ± 4.501	58.87 ± 8.591,2	< 0.001

Values are expressed as mean ± SD. Comparison between groups was tested by One way analysis of variance followed by Tuckey’s post hoc test.

¹Statistically significant as compared to normal weight;

²Statistically significant as compared to overweight. Significance set at P value < 0.05. HOMA-IR: Homeostasis model of insulin resistance; QUICKI: Quantitative insulin sensitivity check index; HDL: High density lipoprotein; LDL: Low density lipoprotein; TNF: Tumor necrosis factor; WHR: Waist to hip ratio.