Epigenetic profiles of pre-diabetes transitioning to type 2 diabetes and nephropathy

Figure 3 Hypo-methylated kidney disease associated gene loci. Six putative genes related to kidney disease were hypomethylated across patients (numbered 1-11) compared to controls (n = 2). Red bars indicate diabetic time point and blue bars representing prediabetic time point. Data represented as DiffScore with ± 13 equating to P-value 0.05, ± 22 equating to P-value of 0.01, and ± 33 equating to P-value of 0.001. SLC22A12 (a urate transporter on the proximal tubule); TRPM6 (a cation channel in the kidney); AQP9 (an aquaporin); HP (haptoglobin, which binds plasma hemoglobin); AGXT (alanine-glyoxylate aminotransferase which is involved in oxalic acid secretion); HYAL2 (a hyaluronidase).