Review
Copyright ©The Author(s) 2015.
World J Diabetes. Jul 25, 2015; 6(8): 1057-1064
Published online Jul 25, 2015. doi: 10.4239/wjd.v6.i8.1057
Figure 1
Figure 1 Schematic overview of the metabolism of vitamin D. Synthesis of vitamin D3 starts in the skin where 7-dehydrocholesterol is converted into vitamin D3 in response to UVB exposure. Vitamin D3 is hydroxylated by 25-hydroxylases in the liver. The resulting 25-hydroxyvitamin D3 is then hydroxylated in the kidney by 1α hydroxylase, to produce the final activated product, 1,25-dihydroxyvitamin D3.