Review
Copyright ©The Author(s) 2015.
World J Diabetes. Jun 10, 2015; 6(5): 693-706
Published online Jun 10, 2015. doi: 10.4239/wjd.v6.i5.693
Table 5 Interventional studies (diabetes as a binary variable) and outcomes related to hyperglycaemia (chronological order)
Ref.YearStudy ptsStudy pointNon diabetic patientsDiabetic patientsOverall message
1Van den Berghe et al[54]20062748ITT (blood glucose 4.4-6.1 mmol/L) vs CIT (insulin if blood glucose > 12 then target 10-11.1 mmol/L) on mortalityReduced mortality and morbidity with ITTNo survival benefit with ITTHigher rates of hypoglycaemiaHosp mortality 20% (40/200) of the DM patients in conventional arm Hosp mortality 22% (46/207) of the DM patients in the ITT arm
Arabi et al[39]2008523ITT (blood glucose 4.4-6.1 mmol/L) vs CIT (blood glucose 10-11.1 mmol/L) on ICU mortalityMortality: ITT (14%) vs CIT (14%) - no significant difference (P = 0.2)Mortality: ITT (13%) vs CIT (20%) - no significant difference (P = 0.3)No significant difference in ICU mortality between IIT and CIT (P = 0.3)
Brunkhorst et al[38]2008537ITT (blood glucose 4.4-6.1 mmol/L) vs CIT (blood glucose 10-11.1 mmol/L) on mortality28 d mortality: ITT 25% vs CIT 23% (P = 0.8)90 d mortality: ITT 40% vs CIT 32% (P = 0.2)28 d mortality: ITT 25% vs CIT 32% (P = 0.3)90 d mortality: ITT 40% vs CIT 42% (P = 0.9)No mortality benefit with ITT vs CITStopped early due to safety risk
Del La Rosa et al[42]2008504ITT (blood glucose 4.4-6.1 mmol/L) vs CIT (blood glucose 10-11.1 mmol/L) on morbidity and mortalityICU mortality ITT 37% vs CIT 32% (no significance)2In-hospital mortality: ITT 40% vs CIT 39% (no significance)2Mortality: ITT (38%) vs CIT (31%) - no significant differenceNo difference in ICU mortality, 28 d mortality or ICU infectionsIncreased hypoglycaemia in ITT
Finfer et al[41]20096029ITT (blood glucose 4.4-6.1 mmol/L) vs CIT (blood glucose < 10 mmol/L) on mortalityMortality: ITT (27%) vs CIT (24%) - no significant differenceMortality: ITT (32%) vs CIT (28%) - no significant differenceITT arm - inc 90 d mortalityNo difference in those with and without DM (P = 0.60)
Preiser et al[40]20091078ITT (blood glucose 4.4-6.1 mmol/L) vs CIT (blood glucose 7.8-10 mmol/L) on mortalityICU mortality ITT 17% vs CIT 15% (P = 0.4) 2Hospital mortality: ITT 23% vs CIT 19% (P = 0.1)2Not describedStopped early due to protocol violations