Type 2 diabetes mellitus: From a metabolic disorder to an inflammatory condition

doi:10.4239/wjd.v6.i4.598

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World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Diabetes. May 15, 2015; 6(4): 598-612
Published online May 15, 2015. doi: 10.4239/wjd.v6.i4.598

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Figure 5 Activation of inflammasomes in type 2 diabetes (metabolic stress activates multiprotein complex, inflammasome in β-cells that induce caspase-1 to cleave pro-interleukin-1β (pro-IL-1β) into active IL-1β. β-cell-derived IL-1β promote the release of chemokines and recruitment of macrophages that are activated by human islet amyloid polypeptide, leading to deleterious concentrations of IL-1β. FFA: Free fatty acid; IL: Interleukin.

Citation: Hameed I, Masoodi SR, Mir SA, Nabi M, Ghazanfar K, Ganai BA. Type 2 diabetes mellitus: From a metabolic disorder to an inflammatory condition. World J Diabetes 2015; 6(4): 598-612
URL: https://www.wjgnet.com/1948-9358/full/v6/i4/598.htm
DOI: https://dx.doi.org/10.4239/wjd.v6.i4.598