Review
Copyright ©The Author(s) 2015.
World J Diabetes. May 15, 2015; 6(4): 583-597
Published online May 15, 2015. doi: 10.4239/wjd.v6.i4.583
Table 2 Summary of animal model of Type 2 diabetes mellitus
InductionModelMain characteristicsModel uses
Obese modelsob/ob mice db/db mice KK mice KK/Ay mice NZO mice TSOD mice Zucker fatty rat Zucker diabetic fatty rat OLETE ratObesity-induced hyperglycemiaIdentifying factors involved in obesity-induced diabetes Some models show diabetic complications Treatments to improve beta cell function
Non-obese modelsGK rat Cohen diabetic ratHyperglycemia induced by insufficient beta cell functionTreatments to improve beta cell function and beta cell survival
Diet/nutrition induced obesityHigh fat feeding (mice and rat) Desert gerbil Nile grass ratObesity-induced hyperglycemiaTreatments to improve insulin resistance Treatments to improve beta cell function Treatments to prevent diet-induced obesity
Surgical diabetic animalsVMH lesioned dietary Obese diabetic rat Partially pancreatectomized animals (dog, primate, pig and rats)Avoid cytotoxic effects of chemical diabetogens on other body organs Resembles human T2DM due to reduced pancreatic islet beta cell massOccurrence of hyperphagia Pancreatitis
Transgenic/knock-out diabetic animalsUncoupling protein (UCP1) Knock out mice HiAPP micePoor activation of thermogenesis Amyloid deposition in isletsTreatments of obese conditions Increase obesity (energy storage) Treatments to prevent amyloid deposition