Review
Copyright ©2014 Baishideng Publishing Group Inc.
World J Diabetes. Dec 15, 2014; 5(6): 787-795
Published online Dec 15, 2014. doi: 10.4239/wjd.v5.i6.787
Table 1 Association between life-style related diseases and uric acid metabolism
Diseases/statusSUA levelUA productionFocus 1UA excresionFocus 2
T2DMHigh/low
GlucosuriaLowUpGlomerulus
Insulin resistanceHighDownProximal tubule cell
Use of SGLT2 inhibitorLowUp
RetinopathyUpVitreus
MetSHighUpAdipocyte/liver?DownProximal tubule cell
CKDHighUpVascular endothelial cell/inflammatory cellDown/upKidney/intestine
HypertensionHighUp
AtherosclerosisUpVascular endothelial cell/inflammatory cell
Reperfusion injuryUpVascular endothelial cell
Heart failureUpInflammatory cell
Fructose intakeHighUpLiverDown
Sodium intakeHighDown
Thiazide administrationHighDownProximal tubule cell