Antidiabetic treatment, stroke severity and outcome

Table 1 Major studies that have evaluated the effects of antidiabetic agents on stroke severity and outcome

Ref.	Design	n	Agent	Results
Weih et al[14]	Retrospective	146	Sulfonylureas	No effect on stroke severity or outcome
Kunte et al[15]	Retrospective	61	Sulfonylureas	Better neurological and functional outcome at discharge in patients who were on sulfonylureas prior to stroke
Favilla et al[16]	Prospective	1050	Sulfonylureas, metformin, insulin	Less severe stroke on admission in patients who were on sulfonylureas, metformin or insulin prior to stroke than in patients who were not receiving any antidiabetic agent, but no difference in functional outcome and mortality rates at 90 d between the 2 groups Similar stroke severity and outcome between patients treated with different antidiabetic agents prior to stroke (sulfonylureas, metformin and insulin)
Lee et al[17]	Case-control	60	Thiazolidinediones	Enhanced functional recovery in patients treated with thiazolidinediones