Diabetes-related impairment in bone strength is established early in the life course

Table 1 Pooled data from all mice ages 5 to 15 wk

Parameter	mean ± SEMNOD	NOD.scid
Body composition properties (DXA)
Body weight	19.7 ± 0.6	19.9 ± 0.4
BMC	0.37 ± 0.40	0.34 ± 0.30
BMD	0.04 ± 0.04	0.040 ± 0.001
Body fat	2.8 ± 0.1	2.9 ± 0.2
Lean mass	14.7 ± 0.4	14.8 ± 0.2
% Fat	15.8 ± 0.7	16.2 ± 0.7
Trabecular bone properties (microCT)
TV	1.5 ± 0.1	1.5 ± 0.1
BV	0.10 ± 0.01	0.15 ± 0.011
BV/TV	0.06 ± 0.01	0.10 ± 0.011
Tb. Th	0.050 ± 0.002	0.050 ± 0.002
Tb. N	2.3 ± 0.2	2.80 ± 0.11
Tb. MBV	931.9 ± 20.1	922.9 ± 20.7
Tb. TMD	92.2 ± 8.8	124.5 ± 9.71
Cortical bone properties (microCT)
TV	0.19 ± 0.10	0.21 ± 0.01
BV	0.12 ± 0.02	0.120 ± 0.004
BV/TV	0.60 ± 0.01	0.60 ± 0.01
Ct. TMV	801.8 ± 22.5	770.4 ± 17.51
Ct. TMD	1288.5 ± 15.9	1291.6 ± 16.3

¹Indicates significant difference between groups P < 0.05. BMC: Bone mineral content; BMD: Bone mineral density; BV: Bone volume; TV: Total volume (bone plus marrow); BV/TV: Bone volume fraction; Tb. Tk.: Trabecular thickness; Tb. N: Trabecular number; Tb. TMV: Trabecular material volume; Tb. TMD: Trabecular material density; Ct. TMV: Total cortical material volume; Ct. TMD: Total cortical material density; NOD: Non-obese diabetic; NOD.scid: Syngenic non-diabetic.