ApoE isoforms, treatment of diabetes and the risk of coronary heart disease

Table 2 Factors associated with coronary heart disease in the present cohort¹

Factors	Hazard ratio (95% CI)	P value
Age	1.03 (0.98-1.09)	0.22
Male	1.44 (0.77-2.69)	0.26
Present smokers	0.62 (0.35-1.1)	0.071
Height (m)	0.006 (0.00-1.56)	0.11
BMI (compared with 22 ≤ BMI < 25) (kg/m2)
BMI < 18.5	0.80 (0.18-3.56)	0.78
18.5 ≤ BMI < 22	1.94 (0.88-4.28)	0.10
BMI ≥ 25	1.58 (0.80-3.14)	0.19
HbA1c	1.18 (1.04-1.34)	0.013
Systolic blood pressure	1.02 (1.01-1.04)	0.002
Diastolic blood pressure	1.01 (0.99-1.04)	0.52
Total cholesterol	1.00 (0.99-1.01)	0.38
HDL-cholesterol	0.97 (0.94-1.00)	0.027
LDL-cholesterol	1.00 (0.99-1.00)	0.26
Triglyceride	1.00 (0.99-1.00)	0.32
Diabetic retinopathy	2.77 (1.57-4.93)	0.0005
Proteinuria	1.22 (0.63-2.36)	0.55
ApoE phenotype (compared with apoE3 homozygosity)
ApoE2	0.76 (0.27-2.13)	0.60
ApoE4	0.72 (0.21-2.43)	0.60

¹Univariate analysis. BMI: Body mass index; ApoE: Apolipoprotein E gene; HDL: High density lipoprotein; LDL: Low density lipoprotein.