Ginsenoside Rd promote the contact between mitochondria and lipid droplets through Plin1/Mfn2 to treat diabetic kidney disease

Figure 2 Ginsenoside Rd can inhibit renal interstitial fibrosis in db/db mice. A: Hematoxylin and eosin staining in kidney. Scale bar, 100 μm; B: Masson staining in kidney. Scale bar, 100 μm; C: Periodic acid-Schiff staining in kidney. Scale bar, 100 μm; D: Immunohistochemical images of fibronectin in kidney. Scale bar, 100 μm; E: Statistical image of the positive area for fibronectin (n = 3); F: Immunohistochemical images of collagen I in kidney. Scale bar, 100 μm; G: Statistical image of the positive area for collagen I (n = 3); H: Immunohistochemical images of α-smooth muscle actin (SMA) in kidney. Scale bar, 100 μm; I: Statistical image of the positive area for α-SMA (n = 3); J: Western blot bands of fibronectin, collagen I and α-SMA; K: Western blot analysis of fibronectin (n = 4); L: Western blot analysis of collagen I (n = 4); M: Western blot analysis of α-SMA (n = 4). Data are presented as mean ± SEM. ^aP < 0.01 compared with control group; ^bP < 0.01 compared with model group. HE: Hematoxylin and eosin; SMA: Smooth muscle actin.