Electroacupuncture alleviates diabetic peripheral neuropathy: Regulates mitochondrial biogenesis and redistribution in peripheral nerve fibers

Figure 2 Electroacupuncture treatment has regulatory effect on peripheral neuropathy and metabolic disorders in streptozotocin-high-fat diet-induced rats. A-D: Behavioral and neurological function was assessed by withdrawal threshold (A), withdrawal latency (B), motor nerve conduction velocities (C), and sensory nerve conduction velocities (D) in different groups after electroacupuncture (EA) treatment; E-K: Basic metabolic indices included blood glucose (E), body weight (F), triglyceride (G), non-esterified fatty acid (H), intraperitoneal glucose tolerance test (I) and area under the curve (J), and insulin (K) in different groups after EA treatment. Data are presented as mean ± SEM (n = 4). ^cP < 0.05. ^dP < 0.01. P indicated electroacupuncture group vs type 2 diabetic peripheral neuropathy group. T2DPN: Type 2 diabetic peripheral neuropathy; EA: Electroacupuncture; MNCV: Motor nerve conduction velocities; SNCV: Sensory nerve conduction velocities; TG: Triglyceride; NEFA: Non-esterified fatty acid; IPGTT: Intraperitoneal glucose tolerance test; AUC: Area under the curve; INS: Insulin.