Electroacupuncture alleviates diabetic peripheral neuropathy: Regulates mitochondrial biogenesis and redistribution in peripheral nerve fibers

Figure 1 Streptozotocin-high-fat diet-induced rats exhibit significant characteristics of type 2 diabetic peripheral neuropathy. A and B: Blood glucose (A) and body weight (B) of rats in the control and type 2 diabetic peripheral neuropathy (T2DPN) groups after streptozotocin (STZ) injection; C and D: Glucose tolerance test (C) and the related area under the curve (D) in the control and T2DPN groups; E-I: Serum levels of insulin (E), triglyceride (F), non-esterified fatty acid (G), low-density lipoprotein (H), and high-density lipoprotein (I) in the control and T2DPN groups; J: Withdrawal threshold; K: Withdrawal latency after STZ injection. Data are presented as mean ± SEM (n = 4). ^aP < 0.05. ^bP < 0.01. P indicated type 2 diabetic peripheral neuropathy group vs control group. STZ: Streptozotocin; T2DPN: Type 2 diabetic peripheral neuropathy; GTT: Glucose tolerance test; AUC: Area under the curve; Ctrl: Control; INS: Insulin; TG: Triglyceride; NEFA: Non-esterified fatty acid; LDL: Low-density lipoprotein; HDL: High-density lipoprotein.