Clinical significance of bone metabolic markers in osteoporosis-complicated type 2 diabetes mellitus and risk determinants: A retrospective study

doi:10.4239/wjd.123389

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World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Study

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Diabetes. Aug 15, 2026; 17(8): 123389
Published online Aug 15, 2026. doi: 10.4239/wjd.123389

Table 5 Multivariate regression analysis of risk determinants for osteoporosis in type 2 diabetes mellitus

Variable	β	SE	Wald	P value	OR	95%CI
Constant	-4.121	1.354	9.260	0.002	0.016
Age (years)	0.040	0.018	5.061	0.024	1.040	1.005-1.077
HbA1c (%)	0.082	0.066	1.508	0.219	1.085	0.953-1.236
PTH	0.017	0.005	11.872	0.001	1.017	1.007-1.027
β-CTX	0.269	0.404	0.443	0.506	1.308	0.593-2.889
Disease course (years)	-0.004	0.023	0.032	0.859	0.996	0.954-1.042
Smoking history (0 = no, 1 = yes)	-0.201	0.480	0.176	0.675	0.818	0.319-2.094

HbA1c: Glycosylated hemoglobin; PTH: Parathyroid hormone; β-CTX: Β-C-terminal cross-linked peptide of type I collagen; OR: Odds ratio; CI: Confidence interval.

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Citation: Lu HL, Yu F, Zhou HF, Hu P, Gan SL. Clinical significance of bone metabolic markers in osteoporosis-complicated type 2 diabetes mellitus and risk determinants: A retrospective study. World J Diabetes 2026; 17(8): 123389
URL: https://www.wjgnet.com/1948-9358/full/v17/i8/123389.htm
DOI: https://dx.doi.org/10.4239/wjd.123389

Lu HL, Yu F, Zhou HF, Hu P, Gan SL. Clinical significance of bone metabolic markers in osteoporosis-complicated type 2 diabetes mellitus and risk determinants: A retrospective study. World J Diabetes 2026; 17(8): 123389 [DOI: 10.4239/wjd.123389]

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