Non-antibody biomarkers for differentiating ketosis-onset diabetes: A retrospective study

doi:10.4239/wjd.122101

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World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Study

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Diabetes. Aug 15, 2026; 17(8): 122101
Published online Aug 15, 2026. doi: 10.4239/wjd.122101

Table 6 Receiver operating characteristic analysis for differentiating latent autoimmune diabetes in adult from ketosis-prone type 2 diabetes mellitus

Variable	AUC	Sensitivity	Specificity	Optimal cut-off	P value
2hCP (ng/mL)	0.85	0.86	0.77	< 0.98	< 0.001
HDL-C (mmol/L)	0.79	0.73	0.86	> 1.03	< 0.001
GGT (U/L)	0.79	0.95	0.56	< 37.85	< 0.001
HOMA-IR (C-peptide)	0.70	0.80	0.61	< 4.01	< 0.001

2hCP: 2 hours C-peptide; HDL-C: High-density lipoprotein cholesterol; GGT: Gamma-glutamyl transferase; HOMA: Homeostasis model assessment; IR: Insulin resistance; AUC: Area under the curve.

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Citation: Pei SQ, Ren JL, Zhang L, Gao YX, Yang X, Liu X, Li SN, Liu P, Xu XY. Non-antibody biomarkers for differentiating ketosis-onset diabetes: A retrospective study. World J Diabetes 2026; 17(8): 122101
URL: https://www.wjgnet.com/1948-9358/full/v17/i8/122101.htm
DOI: https://dx.doi.org/10.4239/wjd.122101

Pei SQ, Ren JL, Zhang L, Gao YX, Yang X, Liu X, Li SN, Liu P, Xu XY. Non-antibody biomarkers for differentiating ketosis-onset diabetes: A retrospective study. World J Diabetes 2026; 17(8): 122101 [DOI: 10.4239/wjd.122101]

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