Visceral fat area and red-blood-cell-related indices in adults with type 2 diabetes: Cross-sectional evidence of nonlinear associations

Table 2 Association between visceral fat area and hematological indices after multiple imputation (n = 1180)

Exposure	Non-adjusted		Adjust I		Adjust II
	β (95%CI)	P value	β (95%CI)	P value	β (95%CI)	P value
RBC100
VFA	0.27 (0.20-0.35)	< 0.0001	0.15 (0.09-0.22)	< 0.0001	0.20 (0.14-0.26)	< 0.0001
Q1	1.0		1.0		1.0
Q2	9.73 (1.76-17.71)	0.0168	10.60 (4.02-17.18)	0.0016	11.98 (5.74-18.21)	0.0002
Q3	16.33 (8.39-24.28)	< 0.0001	13.44 (6.83-20.05)	< 0.0001	18.69 (12.36-25.03)	< 0.0001
Q4	27.42 (19.45-35.38)	< 0.0001	13.52 (6.85-20.19)	< 0.0001	18.34 (11.91-24.77)	< 0.0001
P for trend	< 0.0001		< 0.0001		< 0.0001
HGB
VFA	0.09 (0.07-0.11)	< 0.0001	0.05 (0.03-0.06)	< 0.0001	0.05 (0.04-0.07)	< 0.0001
Q1	1.0		1.0		1.0
Q2	2.20 (-0.11 to 4.51)	0.0620	2.30 (0.42-4.18)	0.0164	2.41 (0.62-4.19)	0.0082
Q3	4.54 (2.24-6.84)	0.0001	2.94 (1.06-4.83)	0.0022	3.86 (2.05-5.67)	< 0.0001
Q4	8.47 (6.16-10.78)	< 0.0001	3.97 (2.06-5.87)	< 0.0001	4.65 (2.81-6.49)	< 0.0001
P for trend	< 0.0001		< 0.0001		< 0.0001
HCT100
VFA	0.02 (0.02-0.03)	< 0.0001	0.01 (0.01-0.02)	< 0.0001	0.02 (0.01-0.02)	< 0.0001
Q1	1.0		1.0		1.0
Q2	0.75 (0.12-1.39)	0.0205	0.78 (0.24-1.32)	0.0049	0.84 (0.32-1.35)	0.0015
Q3	1.18 (0.55-1.82)	0.0003	0.81 (0.26-1.35)	0.0038	1.17 (0.64-1.69)	< 0.0001
Q4	2.32 (1.69-2.96)	< 0.0001	1.22 (0.67-1.77)	< 0.0001	1.55 (1.02-2.09)	< 0.0001
P for trend	< 0.0001		< 0.0001		< 0.0001
WBC
VFA	0.01 (0.00-0.01)	< 0.0001	0.01 (0.00-0.01)	< 0.0001	0.01 (0.00-0.01)	< 0.0001
Q1	1.0		1.0		1.0
Q2	0.20 (-0.12 to 0.51)	0.2275	0.21 (-0.09 to 0.51)	0.1784	0.22 (-0.08 to 0.53)	0.1478
Q3	0.29 (-0.03 to 0.61)	0.0761	0.33 (0.02-0.64)	0.0349	0.37 (0.06-0.68)	0.0194
Q4	0.85 (0.53-1.17)	< 0.0001	0.69 (0.38-1.01)	< 0.0001	0.72 (0.41-1.04)	< 0.0001
P for trend	< 0.0001		< 0.0001		< 0.0001

Data are regression coefficients (β) and 95% confidence intervals from linear regression models after multiple imputation (n = 1180), examining the associations between visceral fat area and hematological indices. “Non-adjusted” denotes crude models. Model I was adjusted for age and sex. Model II was further adjusted for estimated glomerular filtration rate, current smoking, current drinking, total cholesterol, triglycerides, and glycated hemoglobin. Red blood cell 100 and hematocrit 100 denote the original values multiplied by 100 to facilitate the presentation of regression coefficients. Results for other hematological indices (mean corpuscular volume, mean corpuscular hemoglobin, and mean corpuscular hemoglobin concentration) are provided in Supplementary Table 1. CI: Confidence interval; VFA: Visceral fat area; RBC: Red blood cell; HGB: Hemoglobin; WBC: White blood cell; HCT: Hematocrit.