Non-invasive haemodynamic monitoring to individualise fluid resuscitation in adult diabetic ketoacidosis: A randomized controlled pilot trial

Table 1 Schedule of enrollment, interventions, and outcome assessments

Outcome	Admission	First fluid resuscitation	Day 1	Day 2	Day 3	Last fluid resuscitation	Day 4	…	Day 13	Day 14	Discharge
Fluid replacement	-	-	1, 2	1, 2	1, 2	-	1	1	1	1	-
Days of hospitalisation	-	-	-	-	-	-	-	-	-	-	1, 2
Complications	-	1	1	1	1	1	1	1	1	1	1, 2
Time to urine ketone conversion	-	-	1	1	1	-	1	1	1	1	1, 2
Blood glucose	1, 2	-	1, 2	1	1, 2	-	1	1	1	1	1
USCOM technical parameters	-	1, 2	1	1	1	1, 2	-	-	-	-	-

¹Indicates that the outcome was measured at the corresponding time point.

²Indicates that data from that time point are reported in the results section.

Timing of measurements for prespecified trial outcomes from admission through day 14 and hospital discharge, including fluid replacement, length of hospitalisation, complications, time to urinary ketone clearance, blood glucose and ultrasonic cardiac output monitor-derived haemodynamic parameters. USCOM: Ultrasonic cardiac output monitor.