Risk stratification model for diabetic kidney disease progression based on metabolic and inflammatory biomarkers

doi:10.4239/wjd.121173

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World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Cohort Study

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Diabetes. Aug 15, 2026; 17(8): 121173
Published online Aug 15, 2026. doi: 10.4239/wjd.121173

Table 3 External validation cohort performance metrics (n = 215)

Metric	Value	95%CI
Discrimination
Overall C-index	0.826	0.779-0.873
Time-dependent AUC at 1 year	0.845	0.798-0.892
Time-dependent AUC at 2 years	0.833	0.783-0.883
Time-dependent AUC at 3 years	0.821	0.769-0.873
Calibration
Calibration slope at 1 year	1.02
Calibration slope at 2 years	0.99
Calibration slope at 3 years	0.97
Risk stratification (3-year progression rate)
Low-risk group	9.3%
Intermediate-risk group	26.7%
High-risk group	61.8%

Calibration intercepts were close to zero at all time points. Risk stratification results closely mirror the derivation cohort findings. AUC: Area under the curve.

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Citation: Du N, Li WX, Qiu CY, Wang J. Risk stratification model for diabetic kidney disease progression based on metabolic and inflammatory biomarkers. World J Diabetes 2026; 17(8): 121173
URL: https://www.wjgnet.com/1948-9358/full/v17/i8/121173.htm
DOI: https://dx.doi.org/10.4239/wjd.121173

Du N, Li WX, Qiu CY, Wang J. Risk stratification model for diabetic kidney disease progression based on metabolic and inflammatory biomarkers. World J Diabetes 2026; 17(8): 121173 [DOI: 10.4239/wjd.121173]

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