Maternally inherited type 2 diabetes mellitus may be associated with mitochondrial tRNAThr mutations

doi:10.4239/wjd.121165

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World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Diabetes. Aug 15, 2026; 17(8): 121165
Published online Aug 15, 2026. doi: 10.4239/wjd.121165

Table 4 Molecular characteristics of type 2 diabetes mellitus-associated G15927A, G15930A, and A15951G mutations

Gene	Nucleotide changes	CI (%)	Number of nucleotides in tRNA	Location in tRNA	Watson-Crick base pairing	Disease association
tRNA^Thr	G15927A	100	42	Anticodon stem	Disrupt 28C-42G base pairing	NSHL; LHON; CHD; DCM
tRNA^Thr	G15930A	50	45	Variable region	-	NSHL
tRNA^Thr	A15951G	100	71	Acceptor arm	Disrupts 2T-71A base pairing	LHON

CHD: Coronary heart disease; CI: Conservation index; DCM: Dilated cardiomyopathy; LHON: Leber hereditary optic neuropathy; NSHL: Nonsyndromic hearing loss.

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Citation: Yu XJ, Ding Y. Maternally inherited type 2 diabetes mellitus may be associated with mitochondrial tRNA^Thr mutations. World J Diabetes 2026; 17(8): 121165
URL: https://www.wjgnet.com/1948-9358/full/v17/i8/121165.htm
DOI: https://dx.doi.org/10.4239/wjd.121165

Yu XJ, Ding Y. Maternally inherited type 2 diabetes mellitus may be associated with mitochondrial tRNA^Thr mutations. World J Diabetes 2026; 17(8): 121165 [DOI: 10.4239/wjd.121165]

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