Maternally inherited type 2 diabetes mellitus may be associated with mitochondrial tRNAThr mutations

doi:10.4239/wjd.121165

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World Journal of Diabetes

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1948-9358

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Diabetes. Aug 15, 2026; 17(8): 121165
Published online Aug 15, 2026. doi: 10.4239/wjd.121165

Table 1 Clinical and molecular features of several affected subjects with type 2 diabetes mellitus

Subjects	Sex	Smoking status	BMI (kg/m²)	Age at examination (years)	Age at onset (years)	BP (mmHg)	Ketoacidosis	PTA (left/right) (dB)	Degree of hearing loss	Visual acuity (left/right)	Degree of visual impairment	Functional mtDNA mutations
DM-005: II-4	Female	-	25	79	62	110/70	No	100/90	Profound	0.02/0.05	Severe	tRNA^Thr G15927A
DM-005: II-6	Female	-	27	74	63	110/70	Yes	85/75	Severe	0.1/0.1	Moderate	tRNA^Thr G15927A
DM-010: II-1	Male	+	23	72	69	113/86	No	55/20	Mild	0.3/0.2	Mild	tRNA^Thr G15930A and A15951G
DM-010: II-8	Female	-	21	75	64	130/89	No	66/70	Severe	0.2/0.2	Mild	tRNA^Thr G15930A and A15951G
DM-010: III-4	Female	+	22	50	48	107/73	Yes	20/15	Normal	0.5/0.5	Normal	tRNA^Thr G15930A and A15951G

BMI: Body mass index; BP: Blood pressure; dB: Decibel; DM: Diabetes mellitus; mtDNA: Mitochondrial DNA; PTA: Pure-tone average.

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Citation: Yu XJ, Ding Y. Maternally inherited type 2 diabetes mellitus may be associated with mitochondrial tRNA^Thr mutations. World J Diabetes 2026; 17(8): 121165
URL: https://www.wjgnet.com/1948-9358/full/v17/i8/121165.htm
DOI: https://dx.doi.org/10.4239/wjd.121165

Yu XJ, Ding Y. Maternally inherited type 2 diabetes mellitus may be associated with mitochondrial tRNA^Thr mutations. World J Diabetes 2026; 17(8): 121165 [DOI: 10.4239/wjd.121165]

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