Role of CCM3 in lead-induced neurological damage in diabetes

doi:10.4239/wjd.113938

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World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Diabetes. Aug 15, 2026; 17(8): 113938
Published online Aug 15, 2026. doi: 10.4239/wjd.113938

Table 6 Interaction of urinary lead levels, blood glucose levels and rs6784267 locus with four neurotransmitter metabolites

Interactive factors	Target	F value	P value
Urinary lead × blood sugar	VMA	14.298	< 0.001
	5-HIAA	0.911	0.404
	DOPAC	2.693	0.070
	HVA	7.856	< 0.001
Urinary lead × rs6784267 locus	VMA	14.939	< 0.001
	5-HIAA	0.116	0.891
	DOPAC	2.274	0.105
	HVA	7.031	< 0.001
Blood sugar × rs6784267 locus	VMA	5.038	0.007
	5-HIAA	2.282	0.104
	DOPAC	0.792	0.454
	HVA	1.955	0.144
Urinary lead × blood sugar × rs6784267 locus	VMA	9.838	< 0.001
	5-HIAA	0.856	0.465
	DOPAC	1.984	0.118
	HVA	4.788	0.003

VMA: Vanillylmandelic acid; HVA: Homovanillic acid; DOPAC: 3,4-dihydroxyphenylacetic acid; 5-HIAA: 5-hydroxyindole acetic acid.

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Citation: Liang X, Yang LX, Tao T, Ding WJ, Tang XY, Shang ZB, Zhou H, He Y, Sun Y. Role of CCM3 in lead-induced neurological damage in diabetes. World J Diabetes 2026; 17(8): 113938
URL: https://www.wjgnet.com/1948-9358/full/v17/i8/113938.htm
DOI: https://dx.doi.org/10.4239/wjd.113938

Liang X, Yang LX, Tao T, Ding WJ, Tang XY, Shang ZB, Zhou H, He Y, Sun Y. Role of CCM3 in lead-induced neurological damage in diabetes. World J Diabetes 2026; 17(8): 113938 [DOI: 10.4239/wjd.113938]

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