Regulatory effects of Dangua Fang on the NAMPT/NAD+/SIRT1 axis and amino acid metabolism in type 2 diabetic rats

doi:10.4239/wjd.121202

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World Journal of Diabetes

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1948-9358

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World J Diabetes. Jul 15, 2026; 17(7): 121202
Published online Jul 15, 2026. doi: 10.4239/wjd.121202

Table 5 Comparison of nicotinamide phosphoribosyltransferase/nicotinamide adenine dinucleotide/sirtuin 1 axis expression, mean ± SD

Group	NAD⁺	NAMPT			SIRT1
Group	NAD⁺	mRNA	Protein	Positive area (%)	mRNA	Protein	Positive area (%)
CON	77.12 ± 13.19	1.28 ± 0.21	1.69 ± 0.21	58.75 ± 7.55	1.18 ± 0.19	1.37 ± 0.21	61.14 ± 6.09
MOD	9.62 ± 3.22^a	0.73 ± 0.22^a	0.82 ± 0.22^a	19.77 ± 3.92^a	0.56 ± 0.23^a	0.81 ± 0.19^a	23.67 ± 3.98^a
DFG	26.34 ± 7.73^c	1.08 ± 0.23^c	1.54 ± 0.23^c	43.83 ± 5.31^c	0.99 ± 0.20^c	1.24 ± 0.24^c	47.77 ± 5.03^c
MET	29.63 ± 10.68^c	1.01 ± 0.22^b	1.49 ± 0.19^c	50.22 ± 5.34^c	1.04 ± 0.18^c	1.29 ± 0.23^c	36.21 ± 5.08^c

^aP < 0.01 vs the control group.

^bP < 0.05 vs the model group.

^cP < 0.01 vs the model group.

n = 8 per group. CON: Control group; MOD: Model group; DFG: Dangua Fang group; MET: Metformin group; NAD⁺: Nicotinamide adenine dinucleotide; NAMPT: Nicotinamide phosphoribosyltransferase; SIRT1: Sirtuin 1.

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Citation: Han Z, Wang ZT, Yang LQ, Heng XP. Regulatory effects of Dangua Fang on the NAMPT/NAD⁺/SIRT1 axis and amino acid metabolism in type 2 diabetic rats. World J Diabetes 2026; 17(7): 121202
URL: https://www.wjgnet.com/1948-9358/full/v17/i7/121202.htm
DOI: https://dx.doi.org/10.4239/wjd.121202

Han Z, Wang ZT, Yang LQ, Heng XP. Regulatory effects of Dangua Fang on the NAMPT/NAD⁺/SIRT1 axis and amino acid metabolism in type 2 diabetic rats. World J Diabetes 2026; 17(7): 121202 [DOI: 10.4239/wjd.121202]

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