Regulatory effects of Dangua Fang on the NAMPT/NAD+/SIRT1 axis and amino acid metabolism in type 2 diabetic rats

doi:10.4239/wjd.121202

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World Journal of Diabetes

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1948-9358

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Diabetes. Jul 15, 2026; 17(7): 121202
Published online Jul 15, 2026. doi: 10.4239/wjd.121202

Table 4 Comparison of glucolipid metabolism-related indicators, mean ± SD

Group	Liver weight (g)	Liver index (%)	HbA1c (mg/L)	TC (mmol/L)	TG (mmol/L)	HDL-C (mmol/L)	LDL-C (mmol/L)	FFA (mmol/L)
CON	12.32 ± 2.75	3.28 ± 1.22	0.52 ± 0.08	2.27 ± 1.34	4.09 ± 1.38	1.60 ± 0.28	0.15 ± 0.08	0.80 ± 0.24
MOD	24.79 ± 2.75^a	8.39 ± 2.39^a	1.82 ± 0.25^a	22.12 ± 2.45^a	11.08 ± 2.62^a	0.85 ± 0.25^a	1.40 ± 0.18^a	1.55 ± 0.33^a
DFG	21.53 ± 2.78^b	6.15 ± 1.66^b	1.23 ± 0.21^c	11.16 ± 1.66^c	9.09 ± 2.08	1.01 ± 0.23	0.87 ± 0.15^c	0.73 ± 0.26^c
MET	21.02 ± 2.55^b	5.86 ± 1.57^b	0.98 ± 0.16^c	10.88 ± 2.42^c	8.77 ± 2.17^b	1.05 ± 0.22	0.80 ± 0.14^c	0.65 ± 0.24^c

^aP < 0.01 vs the control group.

^bP < 0.05 vs the model group.

^cP < 0.01 vs the model group.

n = 8 per group. CON: Control group; MOD: Model group; DFG: Dangua Fang group; MET: Metformin group; HbA1c: Haemoglobin A1c; TC: Total cholesterol; TG: Triglycerides; HDL-C: High-density lipoprotein cholesterol; LDL-C: Low-density lipoprotein cholesterol; FFA: Free fatty acids.

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Citation: Han Z, Wang ZT, Yang LQ, Heng XP. Regulatory effects of Dangua Fang on the NAMPT/NAD⁺/SIRT1 axis and amino acid metabolism in type 2 diabetic rats. World J Diabetes 2026; 17(7): 121202
URL: https://www.wjgnet.com/1948-9358/full/v17/i7/121202.htm
DOI: https://dx.doi.org/10.4239/wjd.121202

Han Z, Wang ZT, Yang LQ, Heng XP. Regulatory effects of Dangua Fang on the NAMPT/NAD⁺/SIRT1 axis and amino acid metabolism in type 2 diabetic rats. World J Diabetes 2026; 17(7): 121202 [DOI: 10.4239/wjd.121202]

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