Association between the high-sensitivity C-reactive protein-triglyceride-glucose index and metabolic dysfunction-associated steatotic liver disease across different glycemic states

doi:10.4239/wjd.120647

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World Journal of Diabetes

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1948-9358

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Diabetes. Jul 15, 2026; 17(7): 120647
Published online Jul 15, 2026. doi: 10.4239/wjd.120647

Table 5 Receiver operating characteristic curve analysis of biomarkers and risk scores for metabolic dysfunction-associated steatotic liver disease prediction in different glycemic status

	AUC	95%CI	Cut off value	Sensitivity	Specificity	P for difference in AUC
NGR (n = 2933)
CTI	0.792	0.776-0.809	8.596	0.730	0.723	Ref.
TyG	0.787	0.771-0.804	8.465	0.772	0.662	< 0.001
hs-CRP	0.650	0.630-0.670	1.205	0.598	0.635	< 0.001
FIB-4	0.523	0.502-0.544	1.174	0.671	0.379	< 0.001
NFS	0.509	0.487-0.530	-2.418	0.457	0.576	< 0.001
APRI	0.590	0.570-0.611	0.255	0.565	0.578	< 0.001
ALT	0.741	0.723-0.760	19.500	0.695	0.686	< 0.001
AST	0.638	0.618-0.658	22.500	0.556	0.655	< 0.001
Anthropometric indices¹	0.887	0.875-0.899	/	0.825	0.795	< 0.001
Anthropometric indices¹ + CTI	0.891	0.880-0.903	/	0.848	0.778	< 0.001
Conventional risk factors²	0.832	0.818-0.847	/	0.809	0.710	< 0.001
Conventional risk factors² + CTI	0.834	0.820-0.849	/	0.827	0.697	< 0.001
Pre-DM (n = 3549)
CTI	0.783	0.767-0.798	8.908	0.715	0.711	Ref.
TyG	0.772	0.756-0.788	8.719	0.737	0.677	< 0.001
hs-CRP	0.650	0.631-0.669	1.205	0.687	0.560	< 0.001
FIB-4	0.596	0.576-0.615	1.403	0.729	0.409	< 0.001
NFS	0.542	0.523-0.562	-1.756	0.728	0.337	< 0.001
APRI	0.561	0.542-0.581	0.244	0.637	0.452	< 0.001
ALT	0.733	0.716-0.750	21.500	0.666	0.687	< 0.001
AST	0.608	0.589-0.627	23.500	0.538	0.616	< 0.001
Anthropometric indices¹	0.853	0.840-0.865	/	0.722	0.82	< 0.001
Anthropometric indices¹ + CTI	0.859	0.847-0.871	/	0.724	0.829	< 0.001
Conventional risk factors²	0.783	0.767-0.798	/	0.740	0.680	< 0.001
Conventional risk factors² + CTI	0.786	0.770-0.801	/	0.744	0.682	< 0.001
DM (n = 931)
CTI	0.749	0.712-0.786	9.456	0.668	0.707	Ref.
TyG	0.750	0.713-0.787	9.070	0.763	0.606	< 0.001
hs-CRP	0.615	0.571-0.658	1.395	0.643	0.551	< 0.001
FIB-4	0.627	0.583-0.671	1.568	0.745	0.470	< 0.001
NFS	0.616	0.572-0.661	-0.882	0.528	0.667	< 0.001
APRI	0.573	0.529-0.617	0.271	0.554	0.576	< 0.001
ALT	0.738	0.700-0.775	21.500	0.668	0.702	< 0.001
AST	0.637	0.596-0.678	26.500	0.364	0.864	< 0.001
Anthropometric indices¹	0.790	0.755-0.824	/	0.701	0.722	< 0.001
Anthropometric indices¹ + CTI	0.801	0.767-0.835	/	0.799	0.646	< 0.001
Conventional risk factors²	0.740	0.702-0.778	/	0.700	0.657	< 0.001
Conventional risk factors² + CTI	0.744	0.706-0.782	/	0.696	0.662	< 0.001

¹Anthropometric indices: Body mass index, waist circumference, hip circumference, waist to hip ratio, body roundness index.

²Conventional risk factors: Age, sex, current smoking, current drinking, regular exercise, body mass index, waist circumference, hip circumference, waist to hip ratio, body roundness index, aspartate aminotransferase, alanine aminotransferase, total cholesterol, triglycerides, high-density lipoprotein cholesterol, fasting plasma glucose, systolic blood pressure.

NGR: Normal glucose regulation; Pre-DM: Prediabetes mellitus; DM: Diabetes mellitus AUC: Area under the curve; CTI: C-reactive protein-triglyceride-glucose index; TyG: Triglyceride-glucose index; hs-CRP: High-sensitivity C-reactive protein; FIB-4: Fibrosis-4 index; NFS: Non-alcoholic fatty liver disease fibrosis score; APRI: Aspartate aminotransferase to platelet ratio index; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase.

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Citation: Zhang WH, Shi RDQ, Chen K, Li XM, Yu GH, Ye XY, Xu Q, Ding Y, Luo SH. Association between the high-sensitivity C-reactive protein-triglyceride-glucose index and metabolic dysfunction-associated steatotic liver disease across different glycemic states. World J Diabetes 2026; 17(7): 120647
URL: https://www.wjgnet.com/1948-9358/full/v17/i7/120647.htm
DOI: https://dx.doi.org/10.4239/wjd.120647

Zhang WH, Shi RDQ, Chen K, Li XM, Yu GH, Ye XY, Xu Q, Ding Y, Luo SH. Association between the high-sensitivity C-reactive protein-triglyceride-glucose index and metabolic dysfunction-associated steatotic liver disease across different glycemic states. World J Diabetes 2026; 17(7): 120647 [DOI: 10.4239/wjd.120647]

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