Association between the high-sensitivity C-reactive protein-triglyceride-glucose index and metabolic dysfunction-associated steatotic liver disease across different glycemic states

Table 4 Receiver operating characteristic analysis of biomarkers and risk scores for metabolic dysfunction-associated steatotic liver disease prediction

	AUC	95%CI	Cut off value	Sensitivity	Specificity	P value for difference in AUC
Total
CTI	0.808	0.798-0.817	8.908	0.698	0.769	Ref.
TyG	0.802	0.792-0.812	8.666	0.758	0.697	< 0.001
hs-CRP	0.662	0.649-0.674	1.205	0.662	0.597	< 0.001
FIB-4	0.529	0.516-0.543	1.403	0.733	0.326	< 0.001
NFS	0.541	0.528-0.554	-1.972	0.437	0.630	< 0.001
APRI	0.587	0.574-0.600	0.249	0.608	0.517	< 0.001
ALT	0.748	0.737-0.759	19.500	0.725	0.646	< 0.001
AST	0.633	0.620-0.646	22.500	0.585	0.608	< 0.001
Anthropometric indices1	0.874	0.866-0.882	/	0.791	0.788	< 0.001
Anthropometric indices1 + CTI	0.880	0.872-0.887	/	0.847	0.746	< 0.001
Conventional risk factors2	0.821	0.812-0.831	/	0.840	0.646	< 0.001
Conventional risk factors2 + CTI	0.824	0.814-0.833	/	0.838	0.652	< 0.001

¹Anthropometric indices: Body mass index, waist circumference, hip circumference, waist to hip ratio, body roundness index.

²Conventional risk factors: Age, sex, current smoking, current drinking, regular exercise, body mass index, waist circumference, hip circumference, waist to hip ratio, body roundness index, aspartate aminotransferase, alanine aminotransferase, total cholesterol, triglycerides, high-density lipoprotein cholesterol, fasting plasma glucose, systolic blood pressure.

AUC: Area under the curve; CTI: C-reactive protein-triglyceride-glucose index; TyG: Triglyceride-glucose index; hs-CRP: High-sensitivity C-reactive protein; FIB-4: Fibrosis-4 index; NFS: Non-alcoholic fatty liver disease fibrosis score; APRI: Aspartate aminotransferase to platelet ratio index; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase.