Association between the high-sensitivity C-reactive protein-triglyceride-glucose index and metabolic dysfunction-associated steatotic liver disease across different glycemic states

Table 3 Logistic regression analyses the association between C-reactive protein-triglyceride-glucose index and metabolic dysfunction-associated steatotic liver disease in different glycemic status

Characteristic	Model 1		Model 2		Model 3
	OR (95%CI)	P value	OR (95%CI)	P value	OR (95%CI)	P value
NGR (n = 2933)
CTI (per 1 unit)	5.24 (4.56-6.05)	< 0.001	4.53 (3.63-5.66)	< 0.001	3.07 (2.19-4.31)	< 0.001
CTI quartile
Q1	Ref.	/	Ref.	/	Ref.	/
Q2	3.72 (3.00-4.63)	< 0.001	3.84 (2.75-5.35)	< 0.001	2.62 (1.81-3.81)	< 0.001
Q3	10.00 (7.96-12.70)	< 0.001	7.76 (5.42-11.11)	< 0.001	3.40 (2.17-5.33)	< 0.001
Q4	23.60 (17.40-32.40)	< 0.001	15.41 (9.35-25.39)	< 0.001	5.15 (2.53-10.49)	< 0.001
P for trend	/	< 0.001	/	< 0.001	/	< 0.001
Pre-DM (n = 3549)
CTI (per 1 unit)	5.00 (4.40-5.70)	< 0.001	5.17 (4.24-6.30)	< 0.001	3.26 (1.70-6.23)	< 0.001
CTI quartile
Q1	Ref.	/	Ref.	/	Ref.	/
Q2	2.60 (2.09-3.25)	< 0.001	2.65 (1.92-3.65)	< 0.001	1.77 (0.83-3.78)	< 0.001
Q3	6.65 (5.35-8.31)	< 0.001	6.20 (4.49-8.58)	< 0.001	3.41 (1.47-7.93)	< 0.001
Q4	23.20 (17.80-30.60)	< 0.001	25.20 (16.50-38.50)	< 0.001	5.57 (1.58-19.68)	< 0.001
P for trend	/	< 0.001	/	< 0.001	/	0.002
DM (n = 931)
CTI (per 1 unit)	3.12 (2.52-3.92)	< 0.001	3.33 (2.34-4.75)	< 0.001	1.58 (0.65-3.84)	0.307
CTI quartile
Q1	Ref.	/	Ref.	/	Ref.	/
Q2	2.10 (1.12-3.99)	0.022	3.84 (1.42-10.38)	< 0.001	2.52 (0.62-10.24)	0.196
Q3	3.92 (2.16-7.26)	< 0.001	11.41 (4.22-30.86)	< 0.001	2.64 (0.62-11.20)	0.190
Q4	12.30 (6.89-22.30)	< 0.001	18.09 (7.12-45.95)	< 0.001	2.55 (0.47-13.98)	0.280
P for trend	/	< 0.001	/	< 0.001	/	0.382

Odds ratios were estimated using the following models: Model 1: Unadjusted for any covariates; Model 2: Additionally adjusted for age, sex, current smoking, current drinking, regular exercise; Model 3: Model 2 + additionally adjusted for systolic blood pressure, diastolic blood pressure, hip circumference, aspartate aminotransferase, total protein, total bilirubin, direct bilirubin, total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol, platelet count, albumin, glycated haemoglobin, estimated glomerular filtration rate, blood urea nitrogen, hypertension, hypertriglyceridemia, low HDL-C. NGR: Normal glucose regulation; CTI: C-reactive protein-triglyceride-glucose index; Pre-DM: Prediabetes mellitus; DM: Diabetes mellitus.