Regulation of ferroptosis and mitochondrial homeostasis disruption in diabetic cardiomyopathy: Therapeutic potential of traditional Chinese medicine

doi:10.4239/wjd.120448

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World Journal of Diabetes

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1948-9358

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Diabetes. Jul 15, 2026; 17(7): 120448
Published online Jul 15, 2026. doi: 10.4239/wjd.120448

Table 4 Effects of traditional Chinese medicine-derived bioactive compounds on regulating mitophagy in diabetic cardiomyopathy

Compounds	Herb source	Drug dosage	Model	Mechanisms
Fucoxanthin, FX	Brown seaweed, Undaria pinnatifida (Harvey) Suringar	200 mg/kg/day, 1 μM in vitro	STZ-induced DCM rats; HG-treated H9c2 cells	Alleviates oxidative stress; restores mitophagy; reduces myocardial fibrosis and hypertrophy[154]
Heterophyllin B	Prince ginseng, Pseudostellaria heterophylla (Miq.) Pax	8 mg/kg/day, 20 mg/kg/day, 0.1 μM, 0.5 μM, 1 μM, 5 μM, 10 μM, 50 μM, 100 μM in vitro	STZ-DCM mice; HG-H9c2 cells; HG-NRCMs	MAVS-mediated mitochondrial homeostasis; normalizes mitophagy/autophagic flux (LC3-II balanced, autolysosome↓); ↑OPA1 → fusion↑/fragmentation↓; mitochondrial ROS↓[155]
Tanshinone IIA	Red sage (Danshen), Salvia miltiorrhiza Bunge	10 mg/kg/day, 25 mg/kg/day	STZ-induced DCM rats	Enhances PINK1-Parkin-dependent mitophagy (↑PINK1, Parkin, Beclin-1, LC3II/I; ↓p62); increases LC3-COX IV colocalization; restores mitochondrial ultrastructure & function; improves cardiac function; lowers blood glucose[156]

DCM: Diabetic cardiomyopathy; STZ: Streptozotocin.

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Citation: Tang YT, Wu Q, Chen YP, Xia L, Yang MH, Wei MY, Pang Q, Yang YN, Liu JB, Liu JL, Ni Q, Gong YB. Regulation of ferroptosis and mitochondrial homeostasis disruption in diabetic cardiomyopathy: Therapeutic potential of traditional Chinese medicine. World J Diabetes 2026; 17(7): 120448
URL: https://www.wjgnet.com/1948-9358/full/v17/i7/120448.htm
DOI: https://dx.doi.org/10.4239/wjd.120448

Tang YT, Wu Q, Chen YP, Xia L, Yang MH, Wei MY, Pang Q, Yang YN, Liu JB, Liu JL, Ni Q, Gong YB. Regulation of ferroptosis and mitochondrial homeostasis disruption in diabetic cardiomyopathy: Therapeutic potential of traditional Chinese medicine. World J Diabetes 2026; 17(7): 120448 [DOI: 10.4239/wjd.120448]

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