Can one composite index capture both inflammatory and metabolic cardiovascular risk in type 2 diabetes?

Figure 2 Research roadmap for validation and clinical translation of the C-reactive protein-fasting C-peptide product. The schematic outlines key steps for future investigation, including prospective validation, model comparison with established indices, multi-ethnic calibration, and integration into machine-learning-based risk prediction frameworks. GAM: Generalized additive model; TyG: Triglyceride-glucose; NRI: Net reclassification index; IDI: Integrated discrimination improvement.