Assessment of the role of general control nonderepressible 2 in gestational diabetes mellitus progression and the underlying mechanisms

Figure 5 General control nonderepressible 2 knockdown alleviated endoplasmic reticulum stress-associated mitochondrial dysfunction in placental tissues of gestational diabetes mellitus mice. A: Expression levels of endoplasmic reticulum stress-related proteins determined by Western blotting; B: Mitochondrial ultrastructural changes observed by transmission electron microscopy; C: ATP content in placental tissues. ^aP < 0.001 vs control; ^bP < 0.05 vs gestational diabetes mellitus (GDM) + sh-negative control (NC); ^cP < 0.001 vs GDM + sh-NC. eIF2α: Eukaryotic initiation factor 2α; GCN2: General control nonderepressible 2; GDM: Gestational diabetes mellitus; NC: Negative control.