Assessment of the role of general control nonderepressible 2 in gestational diabetes mellitus progression and the underlying mechanisms

Figure 3 General control nonderepressible 2 knockdown reduced hepatic lipid deposition and restored glycogen accumulation in gestational diabetes mellitus mice. A: Hepatic histological changes assessed by hematoxylin and eosin staining; B: Hepatic lipid accumulation assessed by Oil Red O staining; C: Expression of lipid metabolism-related genes; D: Hepatic glycogen content assessed by Periodic acid-Schiff staining. ^aP < 0.001 vs control; ^bP < 0.01 vs gestational diabetes mellitus (GDM) + sh-negative control (NC); ^cP < 0.001 vs GDM + sh-NC. GCN2: General control nonderepressible 2; GDM: Gestational diabetes mellitus; NC: Negative control.