Dynamic glycemic exposure and trajectory profiling for incident diabetic kidney disease: A longitudinal cohort study

Figure 1 Cumulative incidence curves for incident diabetic kidney disease according to baseline and time-weighted average glycated hemoglobin. A: Standard Kaplan-Meier cumulative incidence curves stratified by baseline glycated hemoglobin (HbA1c); B: Simon-Makuch cumulative incidence curves stratified by time-weighted average HbA1c, analyzed as a time-dependent covariate. Participants were categorized by predefined clinical thresholds: < 7% (class 1), 7%-8% (class 2), and > 8% (class 3). Differences among groups were evaluated by the log-rank test (overall P < 0.001). HbA1c: Glycated hemoglobin.