Hidden metabolic crisis in lean youth: Waist-to-height ratio uncovers endoplasmic reticulum stress-driven insulin resistance in platelets

doi:10.4239/wjd.119998

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World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Diabetes. Jun 15, 2026; 17(6): 119998
Published online Jun 15, 2026. doi: 10.4239/wjd.119998

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Figure 1 The hidden metabolic crisis in lean youth. Waist-to-height ratio > 0.5 identifies high visceral adiposity risk, even in normal-weight individuals. Platelets serve as early biosensors of endoplasmic reticulum stress-driven insulin resistance, enabling precision prevention through routine screening, lifestyle intervention, and future targeted therapies. WtHR: Waist-to-height ratio; BMI: Body mass index; ER: Endoplasmic reticulum; FFAs: Free fatty acids; p-PERK: Phosphorylated protein kinase R-like endoplasmic reticulum kinase; p-JNK: Phosphorylated c-Jun N-terminal kinase; SERCA: Sarco-endoplasmic reticulum Ca-ATPase.

Citation: Han ZG, Yang Y, Huang PY, Yang M, Zhang GD, Yang X, Song CY, Lu JS, Wang KY. Hidden metabolic crisis in lean youth: Waist-to-height ratio uncovers endoplasmic reticulum stress-driven insulin resistance in platelets. World J Diabetes 2026; 17(6): 119998
URL: https://www.wjgnet.com/1948-9358/full/v17/i6/119998.htm
DOI: https://dx.doi.org/10.4239/wjd.119998

Han ZG, Yang Y, Huang PY, Yang M, Zhang GD, Yang X, Song CY, Lu JS, Wang KY. Hidden metabolic crisis in lean youth: Waist-to-height ratio uncovers endoplasmic reticulum stress-driven insulin resistance in platelets. World J Diabetes 2026; 17(6): 119998 [DOI: 10.4239/wjd.119998]

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