Visit-to-visit variability of creatinine levels associated with proteinuria progression in Chinese patients with type 2 diabetes mellitus

Table 2 Mean and standard deviation of the 12 metabolic indexes among type 2 diabetes mellitus patients with and without the proteinuria progression during follow-up, mean ± SD

Variables	T2DM with proteinuria progression (n = 390)	T2DM without proteinuria progression (n = 1063)	t/Z value	P value
BMI (kg/m2)	25.68 ± 3.39	25.09 ± 3.25	2.85	0.04
BMI (kg/m2), median (IQR)	0.87 (0.61-1.17)	0.77 (0.56-1.10)	2.55	0.01
SBP (mmHg)	133.16 ± 12.78	128.44 ± 12.45	5.96	< 0.01
SBP (mmHg), median (IQR)	11.55 (8.91-14.87)	10.50 (7.86-13.45)	3.78	< 0.01
DBP (mmHg)	76.32 ± 8.34	75.83 ± 8.07	0.97	0.33
DBP (mmHg), median (IQR)	6.43 (4.95-8.49)	6.12 (4.62-8.13)	2.27	0.02
FBG (mmol/L)	7.65 ± 2.97	7.15 ± 1.39	4.30	< 0.01
FBG (mmol/L), median (IQR)	3.77 (3.25-4.37)	3.61 (3.18-4.22)	2.64	< 0.01
HbA1c (%)	7.25 ± 1.13	7.02 ± 1.02	3.59	< 0.01
HbA1c (%), median (IQR)	0.88 (0.48-1.49)	0.87 (0.46-1.67)	0.58	0.56
GA (%)	17.44 ± 4.09	16.90 ± 3.58	2.44	0.02
GA (%), median (IQR)	2.73 (1.62-4.64)	2.67 (1.43-4.93)	0.25	0.80
TC (mmol/L)	4.57 ± 0.98	4.57 ± 0.86	0.01	0.99
TC (mmol/L), median (IQR)	0.71 (0.46-1.02)	0.70 (0.44-0.99)	1.00	0.32
TG (mmol/L)	2.00 ± 2.16	1.80 ± 1.41	2.07	0.04
TG (mmol/L), median (IQR)	0.44 (0.26-0.79)	0.43 (0.24-0.71)	1.06	0.29
LDL-C (mmol/L)	2.53 ± 0.69	2.58 ± 0.70	1.20	0.23
LDL-C (mmol/L), median (IQR)	0.55 (0.34-0.83)	0.55 (0.34-0.79)	0.94	0.35
HDL-C (mmol/L)	1.09 ± 0.28	1.10 ± 0.26	0.98	0.33
HDL-C (mmol/L), median (IQR)	0.12 (0.09-0.17)	0.12 (0.81-0.17)	0.59	0.55
Cr (μmol/L)	65.93 ± 25.57	67.13 ± 28.93	0.72	0.47
Cr (μmol/L), median (IQR)	6.01 (3.97-8.71)	5.39 (3.72-7.41)	2.75	< 0.01
UA (μmol/L)	335.44 ± 73.05	334.64 ± 73.85	0.18	0.86
UA (μmol/L), median (IQR)	46.55 (34.14-67.92)	43.66 (30.76-63.77)	2.43	0.02

T2DM: Type 2 diabetes mellitus; IQR: Interquartile range; BMI: Body mass index; SBP: Systolic blood pressure; DBP: Diastolic blood pressure; FBG: Fasting blood glucose; HbA1c: Glycated hemoglobin; GA: Glycated albumin; TC: Total cholesterol; TG: Triglyceride; LDL-C: Low-density lipoprotein cholesterol; HDL-C: High-density lipoprotein cholesterol; Cr: Creatinine; UA: Uric acid.