Zuo Gui pill alleviates M1 macrophage polarization in type 2 diabetic osteoporosis through the Nrf2/HO-1/XCT/GPX4 pathway

doi:10.4239/wjd.v17.i5.117635

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World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Diabetes. May 15, 2026; 17(5): 117635
Published online May 15, 2026. doi: 10.4239/wjd.v17.i5.117635

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Figure 1 Network pharmacological analysis. A: Venn diagram depicting the common target of Zuo Gui pill and type 2 diabetic osteoporosis; B: Protein-protein interaction network of intersecting targets; C: Kyoto Encyclopedia of Genes and Genomes enrichment analysis and WikiPathways analysis; D: Gene Ontology enrichment analysis; E: Binding energy of the active ingredient to the target protein. The darker blue indicates higher binding energies (unit: Kcal/mol). T2DOP: Type 2 diabetic osteoporosis; ZGP: Zuo Gui pill.

Citation: Zhao Y, Feng XZ, Cao WQ, Chen YR, Yang Y, Liu JC, Xu A, Ren YL, Wang ZM. Zuo Gui pill alleviates M1 macrophage polarization in type 2 diabetic osteoporosis through the Nrf2/HO-1/XCT/GPX4 pathway. World J Diabetes 2026; 17(5): 117635
URL: https://www.wjgnet.com/1948-9358/full/v17/i5/117635.htm
DOI: https://dx.doi.org/10.4239/wjd.v17.i5.117635

Zhao Y, Feng XZ, Cao WQ, Chen YR, Yang Y, Liu JC, Xu A, Ren YL, Wang ZM. Zuo Gui pill alleviates M1 macrophage polarization in type 2 diabetic osteoporosis through the Nrf2/HO-1/XCT/GPX4 pathway. World J Diabetes 2026; 17(5): 117635 [DOI: 10.4239/wjd.v17.i5.117635]

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