Association between circulating CTRP12 levels and type 2 diabetes: A meta-analysis

Table 3 The results of subgroup analysis

Subgroup	Number of comparisons	Participants	SMD (95%CI)	Z value	P value	Test of heterogeneity
						I2 (%)	P value
Overall	13	2193	-1.73 (-2.22 to -1.25)	-	-	-	-
FBG	10	1813				0	0.65
7.0-10.0 mmol/L	8	1640	-2.05 (-2.76 to -1.35)	5.7	< 0.00001	97	< 0.00001
> 10.0 mmol/L	2	173	-1.87 (-2.24 to 1.49)	9.74	< 0.00001	0	0.46
FINS	8	1346	-	-	-	0	0.71
≤ 10 μU/mL	4	826	-2.17 (-3.24 to -1.10)	3.99	< 0.00001	97	< 0.00001
> 10 μU/mL	4	520	-2.42 (-3.21 to -1.63)	6.01	< 0.00001	90	< 0.00001
HOMA-IR	9	1644	-	-	-	78.5	0.03
≥ 3.0	7	1330	-2.37 (-3.10 to -1.64)	6.35	< 0.00001	96	< 0.00001
< 3.0	2	314	-1.47 (-1.84 to 1.10)	7.78	< 0.00001	38	0.21
HbA1c	10	1581	-	-	-	0	0.56
< 8.0%	4	619	-1.50 (-2.18 to -0.82)	4.31	< 0.00001	90	< 0.00001
≥ 8.0%	6	962	-1.79 (-2.45 to -1.12)	5.26	< 0.00001	94	< 0.00001
Age	9	1667	-	-	-	7.2	0.3
≤ 55	5	862	-2.08 (-2.99 to -1.17)	4.48	< 0.00001	96	< 0.00001
> 55	4	805	-1.50 (-2.12 to -0.87)	4.69	< 0.00001	93	< 0.00001
BMI	10	1813	-	-	-	91.6	< 0.00001
Normal	1	298	-1.26 (-1.52 to -1.00)	9.44	< 0.00001	-	-
Overweight	8	1455	-1.98 (-2.68 to -1.27)	5.5	< 0.00001	96	< 0.00001
Obese	1	60	-3.24 (-4.02 to -2.45)	8.09	-	-	-
TG	10	1813	-	-	-	60.6	0.11
< 1.7 mmol/L	3	632	-2.77 (-4.08 to -1.47)	4.16	< 0.00001	97	< 0.00001
≥ 1.7 mmol/L	7	1181	-1.65 (-2.11 to -1.19)	7.01	< 0.00001	90	< 0.00001
TC	10	1813	-	-	-	0	0.39
< 5.2 mmol/L	7	1172	-2.20 (-2.88 to -1.51)	6.30	< 0.00001	94	< 0.00001
≥ 5.2 mmol/L	3	641	-1.60 (-2.77 to -0.43)	2.68	< 0.00001	97	< 0.00001
LDL-C	9	1723	-	-	-	0	0.69
< 3 mmol/L	5	820	-1.85 (-2.30 to -1.41)	8.17	< 0.00001	81	< 0.00001
≥ 3 mmol/L	4	903	-2.14 (-3.51 to -0.77)	3.06	< 0.00001	98	0.002
HDL-C	10	1813	-	-	-	62	0.10
< 1.0 mmol/L	2	381	-1.43 (-1.88 to -0.99)	6.30	< 0.00001	59	< 0.00001
≥ 1.0 mmol/L	8	1432	-2.15 (-2.90 to -1.41)	5.65	< 0.00001	96	< 0.00001
Year	13	2193	-	-	-	71.7	0.06
≤ 2020	6	838	-2.38 (-3.49 to -1.26)	4.18	< 0.00001	97	< 0.00001
> 2020	7	1355	-1.27 (-1.55 to -0.99)	8.95	< 0.00001	76	< 0.00001
Race	13	2193	-	-	-	0	0.61
Chinese	10	2031	-1.84 (-2.36 to -1.31)	6.82	< 0.00001	95	< 0.00001
Non-Chinese	3	162	-1.37 (-3.06 to -0.32)	1.59	0.11	94	< 0.00001

SMD: Standardized mean difference; CI: Confidence interval; FPG: Fasting plasma glucose; FINS: Fasting insulin; HOMA-IR: Homeostatic model assessment-insulin resistance; HbA1c: Hemoglobin a1c; BMI: Body mass index; TG: Triglycerides; TC: Total cholesterol; LDL-C: Low-density lipoprotein cholesterol; HDL-C: High-density lipoprotein cholesterol.